Journal of International Oncology ›› 2022, Vol. 49 ›› Issue (12): 759-762.doi: 10.3760/cma.j.cn371439-20220816-00149

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Research progress of ferroptosis in the treatment of leukemia

Zhou Xinyu, Jia Xiuhong()   

  1. Department of Pediatrics, Binzhou Medical University Affiliated Hospital, Binzhou 256603, China
  • Received:2022-06-23 Revised:2022-07-31 Online:2022-12-08 Published:2023-01-05
  • Contact: Jia Xiuhong E-mail:jiaxiuhong001@163.com
  • Supported by:
    Natural Science Foundation of Shandong Province of China(ZR2014HL032);Medical and Health Science and Technology Development Project of Shandong Province of China(2017WS038)

Abstract:

Leukemia is a group of hematologic malignancie. Ferroptosis is a novel of cell death caused by iron-dependent lipid peroxidation accumulation, which participates in the occurrence and development of leukemia. Activation of different regulatory sites in the ferroptosis pathway can promote the death of leukemia cells. Therefore, it can provide a new direction for the treatment of leukemia by inducing ferroptosis of cells.

Key words: Leukemia, Ferroptosis, Therapeutics