Gut microbiota and hematological malignancies

doi:10.3760/cma.j.cn371439-20201019-00086

Abstract

Abstract:

In recent years, driven by metagenomics sequencing technology, it has been found that compositional changes and diversity changes of gut microbiota are related to the occurrence of hematological malignancies. Gut microbiota affects the development of the hematopoietic system and the risk stratification of hematological malignancies. Microbial translocation plays an important role in and blood stream infection. Gut microbiota imbalance and blood stream infection affect the therapeutic effect of hematological malignancies. Probiotics and fecal microbiota transplant can restore the diversity of gut microbiota.

Key words: Microbiota, Hematological neoplasms, Therapy, Microbial translocation, Blood stream infection

Wei Liya, Guo Zhi. Gut microbiota and hematological malignancies[J]. Journal of International Oncology, 2021, 48(7): 445-448.

References 40

[1]	Lynch SV, Pedersen O. The human intestinal microbiome in health and disease[J]. N Engl J Med, 2016, 375(24):2369-2379. DOI: 10.1056/NEJMra1600266. doi: 10.1056/NEJMra1600266
[2]	Josefsdottir KS, Baldridge MT, Kadmon CS, et al. Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota[J]. Blood, 2017, 129(6):729-739. DOI: 10.1182/blood-2016-03-708594. doi: 10.1182/blood-2016-03-708594 pmid: 27879260
[3]	Staffas A, Burgos da Silva M, Slingerland AE, et al. Nutritional support from the intestinal microbiota improves hematopoietic reconstitution after bone marrow transplantation in mice[J]. Cell Host Microbe, 2018, 23(4):447-457, e4. DOI: 10.1016/j.chom.2018.03.002. doi: S1931-3128(18)30099-4 pmid: 29576480
[4]	Jain S, Ward JM, Shin DM, et al. Associations of autoimmunity, immunodeficiency, lymphomagenesis, and gut microbiota in mice with knockins for a pathogenic autoantibody[J]. Am J Pathol, 2017, 187(9):2020-2033. DOI: 10.1016/j.ajpath.2017.05.017. doi: 10.1016/j.ajpath.2017.05.017
[5]	Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation[J]. Cell, 2014, 157(1):121-141. DOI: 10.1016/j.cell.2014.03.011. doi: 10.1016/j.cell.2014.03.011
[6]	Schloss PD, Westcott SL. Assessing and improving methods used in operational taxonomic unit-based approaches for 16S rRNA gene sequence analysis[J]. Appl Environ Microbiol, 2011, 77(10):3219-3226. DOI: 10.1128/AEM.02810-10. doi: 10.1128/AEM.02810-10
[7]	Vijayvargiya P, Jeraldo PR, Thoendel MJ, et al. Application of me-tagenomic shotgun sequencing to detect vector-borne pathogens in clinical blood samples[J]. PLoS One, 2019, 14(10):e0222915. DOI: 10.1371/journal.pone.0222915. doi: 10.1371/journal.pone.0222915
[8]	Dulanto Chiang A, Dekker JP. From the pipeline to the bedside: advances and challenges in clinical metagenomics[J]. J Infect Dis, 2020, 221(Suppl 3):S331-S340. DOI: 10.1093/infdis/jiz151. doi: 10.1093/infdis/jiz151
[9]	Ten Hoopen P, Finn RD, Bongo LA, et al. The metagenomic data life-cycle: standards and best practices[J]. Gigascience, 2017, 6(8):1-11. DOI: 10.1093/gigascience/gix047. doi: 10.1093/gigascience/gix047 pmid: 28637310
[10]	Song Y, Gyarmati P. Optimized detection of bacteria in bloodstream infections[J]. PLoS One, 2019, 14(6):e0219086. DOI: 10.1371/journal.pone.0219086. doi: 10.1371/journal.pone.0219086
[11]	Song Y, Giske CG, Gille-Johnson P, et al. Nuclease-assisted suppression of human DNA background in sepsis[J]. PLoS One, 2014, 9(7):e103610. DOI: 10.1371/journal.pone.0103610. doi: 10.1371/journal.pone.0103610
[12]	Gijavanekar C, Strych U, Fofanov Y, et al. Rare target enrichment for ultrasensitive PCR detection using cot-rehybridization and duplex-specific nuclease[J]. Anal Biochem, 2012, 421(1):81-85. DOI: 10.1016/j.ab.2011.11.010. doi: 10.1016/j.ab.2011.11.010 pmid: 22155054
[13]	Hakim H, Dallas R, Wolf J, et al. Gut microbiome composition predicts infection risk during chemotherapy in children with acute lymphoblastic leukemia[J]. Clin Infect Dis, 2018, 67(4):541-548. DOI: 10.1093/cid/ciy153. doi: 10.1093/cid/ciy153 pmid: 29518185
[14]	Tims S, Derom C, Jonkers DM, et al. Microbiota conservation and BMI signatures in adult monozygotic twins[J]. ISME J, 2013, 7(4):707-717. DOI: 10.1038/ismej.2012.146. doi: 10.1038/ismej.2012.146
[15]	Nearing JT, Connors J, Whitehouse S, et al. Infectious complications are associated with alterations in the gut microbiome in pediatric patients with acute lymphoblastic leukemia[J]. Front Cell Infect Microbiol, 2019, 9:28. DOI: 10.3389/fcimb.2019.00028. doi: 10.3389/fcimb.2019.00028
[16]	Montassier E, Gastinne T, Vangay P, et al. Chemotherapy-driven dysbiosis in the intestinal microbiome[J]. Aliment Pharmacol Ther, 2015, 42(5):515-528. DOI: 10.1111/apt.13302. doi: 10.1111/apt.2015.42.issue-5
[17]	Kaysen A, Heintz-Buschart A, Muller EEL, et al. Integrated meta-omic analyses of the gastrointestinal tract microbiome in patients undergoing allogeneic hematopoietic stem cell transplantation[J]. Transl Res, 2017, 186:79-94, e1. DOI: 10.1016/j.trsl.2017.06.008. doi: S1931-5244(17)30069-5 pmid: 28686852
[18]	Valdes AM, Walter J, Segal E, et al. Role of the gut microbiota in nutrition and health[J]. BMJ, 2018, 361:k2179. DOI: 10.1136/bmj.k2179.
[19]	Galloway-Peña JR, SmithD P, Sahasrabhojane P, et al. The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia[J]. Cancer, 2016, 122(14):2186-2196. DOI: 10.1002/cncr.30039. doi: 10.1002/cncr.30039 pmid: 27142181
[20]	Bindels LB, Neyrinck AM, Salazar N, et al. Non digestible oligosaccharides modulate the gut microbiota to control the development of leukemia and associated cachexia in mice[J]. PLoS One, 2015, 10(6):e0131009. DOI: 10.1371/journal.pone.0131009. doi: 10.1371/journal.pone.0131009
[21]	Feld R. Bloodstream source in cancer patients with febrile neutropenia[J]. Int J Antimicrob Agents, 2008, 32 Suppl 1: S30-S33. DOI: 10.1016/j.ijantimicag.2008.06.017. doi: 10.1016/j.ijantimicag.2008.06.017
[22]	Cheroutre H, Lambolez F, Mucida D. The light and dark sides of intestinal intraepithelial lymphocytes[J]. Nat Rev Immunol, 2011, 11(7):445-456. DOI: 10.1038/nri3007. doi: 10.1038/nri3007
[23]	Galloway-Peña JR, Smith DP, Sahasrabhojane P, et al. Characte-rization of oral and gut microbiome temporal variability in hospitalized cancer patients[J]. Genome Med, 2017, 9(1):21. DOI: 10.1186/s13073-017-0409-1. doi: 10.1186/s13073-017-0409-1 pmid: 28245856
[24]	Desai MS, Seekatz AM, Koropatkin NM, et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility[J]. Cell, 2016, 167(5):1339-1353, e21. DOI: 10.1016/j.cell.2016.10.043. doi: 10.1016/j.cell.2016.10.043
[25]	Lähteenmäki K, Wacklin P, Taskinen M, et al. Haematopoietic stem cell transplantation induces severe dysbiosis in intestinal microbiota of paediatric ALL patients[J]. Bone Marrow Transplant, 2017, 52(10):1479-1482. DOI: 10.1038/bmt.2017.168. doi: 10.1038/bmt.2017.168
[26]	Ingham AC, Kielsen K, Cilieborg MS, et al. Specific gut micro-biome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation[J]. Microbiome, 2019, 7(1):131. DOI: 10.1186/s40168-019-0745-z. doi: 10.1186/s40168-019-0745-z
[27]	Kusakabe S, Fukushima K, Maeda T, et al. Pre- and post-serial metagenomic analysis of gut microbiota as a prognostic factor in patients undergoing haematopoietic stem cell transplantation[J]. Br J Haematol, 2020, 188(3):438-449. DOI: 10.1111/bjh.16205. doi: 10.1111/bjh.v188.3
[28]	Peled JU, Devlin SM, Staffas A, et al. Intestinal microbiota and relapse after hematopoietic-cell transplantation[J]. J Clin Oncol, 2017, 35(15):1650-1659. DOI: 10.1200/JCO.2016.70.3348.
[29]	Khoruts A, Hippen KL, Lemire AM, et al. Toward revision of antimicrobial therapies in hematopoietic stem cell transplantation: target the pathogens, but protect the indigenous microbiota[J]. Transl Res, 2017, 179:116-125. DOI: 10.1016/j.trsl.2016.07.013. doi: 10.1016/j.trsl.2016.07.013
[30]	Montassier E, Al-Ghalith GA, Ward T, et al. Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection[J]. Genome Med, 2016, 8(1):49. DOI: 10.1186/s13073-016-0301-4. doi: 10.1186/s13073-016-0301-4 pmid: 27121964
[31]	Biagi E, Zama D, Rampelli S, et al. Early gut microbiota signature of aGvHD in children given allogeneic hematopoietic cell transplantation for hematological disorders[J]. BMC Med Genomics, 2019, 12(1):49. DOI: 10.1186/s12920-019-0494-7. doi: 10.1186/s12920-019-0494-7
[32]	Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, et al. Pro-biotic supplementation decreases chemotherapy-induced gastrointestinal side effects in patients with acute leukemia[J]. J Pediatr Hematol Oncol, 2019, 41(6):468-472. DOI: 10.1097/MPH.000000-0000001497. doi: 10.1097/MPH.0000000000001497
[33]	Bindels LB, Beck R, Schakman O, et al. Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model[J]. PLoS One, 2012, 7(6):e37971. DOI: 10.1371/journal.pone.0037971. doi: 10.1371/journal.pone.0037971
[34]	Wei W, Sun W, Yu S, et al. Butyrate production from high-fiber diet protects against lymphoma tumor[J]. Leuk Lymphoma, 2016, 57(10):2401-2408. DOI: 10.3109/10428194.2016.1144879. doi: 10.3109/10428194.2016.1144879
[35]	中国抗癌协会肿瘤与微生态专业委员会. 肠道微生态与造血干细胞移植相关性中国专家共识[J]. 国际肿瘤学杂志, 2021, 48(3):129-135. DOI: 10.3760/cma.j.cn371439-20210202-00027.
[36]	McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)[J]. Clin Infect Dis, 2018, 66(7):e1-e48. DOI: 10.1093/cid/cix1085. doi: 10.1093/cid/cix1085
[37]	Innes AJ, Mullish BH, Fernando F, et al. Faecal microbiota transplant: a novel biological approach to extensively drug-resistant organism-related non-relapse mortality[J]. Bone Marrow Transplant, 2017, 52(10):1452-1454. DOI: 10.1038/bmt.2017.151. doi: 10.1038/bmt.2017.151
[38]	Biliński J, Grzesiowski P, Muszyński J, et al. Fecal microbiota transplantation inhibits multidrug-resistant gut pathogens: preliminary report performed in an immunocompromised host[J]. Arch Immunol Ther Exp (Warsz), 2016, 64(3):255-258. DOI: 10.1007/s00005-016-0387-9. doi: 10.1007/s00005-016-0387-9
[39]	de Castro CG Jr, Ganc AJ, Ganc RL, et al. Fecal microbiota transplant after hematopoietic SCT: report of a successful case[J]. Bone Marrow Transplant, 2015, 50(1):145. DOI: 10.1038/bmt.2014.212. doi: 10.1038/bmt.2014.212
[40]	Kaito S, Toya T, Yoshifuji K, et al. Fecal microbiota transplantation with frozen capsules for a patient with refractory acute gut graft-versus-host disease[J]. Blood Adv, 2018, 2(22):3097-3101. DOI: 10.1182/bloodadvances.2018024968. doi: 10.1182/bloodadvances.2018024968