微环境与肿瘤干细胞的发生和发展

doi:10.3760/cma.j.issn.1673-422X.2015.02.012

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (2): 126-129.doi: 10.3760/cma.j.issn.1673-422X.2015.02.012

微环境与肿瘤干细胞的发生和发展

张小影,王晓芳

300060天津医科大学肿瘤医院血液科国家肿瘤临床医学研究中心天津市“肿瘤防治”重点实验室

出版日期:2015-02-08 发布日期:2015-02-02
通讯作者: 王晓芳 E-mail:xiaofangwang2005@163.com
基金资助:
国家自然科学基金(81272562)

Microenvironment and the occurrence and development of cancer stem cells

hang Xiaoying, Wang Xiaofang

Department of Hematology, Tianjin Medical University Cancer Hospital, National Cancer Clinical Medical Research Center, Key Labrotary of Cancer Prevention and Therapy, Tianjin 300060, China

Online:2015-02-08 Published:2015-02-02
Contact: Wang Xiaofang E-mail:xiaofangwang2005@163.com

摘要/Abstract

摘要： 肿瘤的发生发展不仅取决于肿瘤本身，而且离不开肿瘤细胞赖以生存的土壤，即肿瘤微环境。研究证实肿瘤微环境的血管和乏氧变化维持其干细胞的干性，并进一步加强肿瘤的浸润和侵袭能力。从微环境的血管生成和乏氧两方面研究肿瘤发生发展的分子机制可为临床靶向治疗提供新思路。

关键词: 肿瘤干细胞, 新生血管化, 病理性, 细胞低氧, 肿瘤微环境

Abstract: The occurrence and development of tumor depends not only on the tumor itself, but also depends on the soil survival of tumor cells, that is the tumor microenvironment. Studies confirm that the changes of blood vessels and hypoxic of tumor microenvironment maintain the stemness of cancer stem cell, and further strengthen the ability of tumor invasion and metastasis. Studying the molecular mechanism of tumor development from angiogenesis and lack of oxygen can provide new ideas for the clinical targeted therapy.

Key words: Neoplastic stem cells, Neovascularization, pathologic, Cell hypoxia, Tumor microenvironment

张小影,王晓芳. 微环境与肿瘤干细胞的发生和发展[J]. 国际肿瘤学杂志, 2015, 42(2): 126-129.

hang Xiaoying, Wang Xiaofang. Microenvironment and the occurrence and development of cancer stem cells[J]. Journal of International Oncology, 2015, 42(2): 126-129.

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微环境与肿瘤干细胞的发生和发展

Microenvironment and the occurrence and development of cancer stem cells

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