硫化氢在肿瘤发生发展中的作用机制及其供体抗肿瘤作用

doi:10.3760/cma.j.cn371439-20230605-00137

摘要/Abstract

摘要：

硫化氢是人体内的一种气体信号分子，可影响血管新生，调控肿瘤细胞凋亡、自噬，且可与肿瘤微环境中其他信号分子相互作用，通过多种途径抑制肿瘤发生发展。硫化氢供体主要表现为抑制肿瘤进展，许多研究致力于使用各种供体、以平稳的方式释放硫化氢并维持在治疗浓度，传统中药有较大的应用前景。硫化氢作用方式复杂多样，尚需进一步的研究探讨证实，为调控硫化氢的治疗药物提供理论基础。

关键词: 肿瘤, 硫化氢, 血管, 细胞凋亡, 自噬, 肿瘤微环境

Abstract:

Hydrogen sulfide is a gas signaling molecule in the human body that can influence angiogenesis， regulate tumor cell apoptosis and autophagy， and interact with other signaling molecules in the tumor microenvironment. It plays a role in inhibiting tumorigenesis and development through various pathways. Hydrogen sulfide donors primarily exhibit anti-tumor effects， and many studies are focused on using various donors to release hydrogen sulfide in a controlled manner and maintain therapeutic concentrations. Traditional Chinese medicine shows great potential. The mechanisms of hydrogen sulfide action are complex and diverse， and further research is needed to explore and confirm them， providing a theoretical basis for the development of therapeutic drugs regulating hydrogen sulfide.

Key words: Neoplasms, Hydrogen sulfide, Blood vessels, Apoptosis, Autophagy, Tumor microenvironment

朱易, 陈健. 硫化氢在肿瘤发生发展中的作用机制及其供体抗肿瘤作用[J]. 国际肿瘤学杂志, 2023, 50(12): 729-733.

Zhu Yi, Chen Jian. Mechanism of hydrogen sulfide in tumorigenesis and development and its donor-mediated anti-tumor effects[J]. Journal of International Oncology, 2023, 50(12): 729-733.

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