国际肿瘤学杂志 ›› 2024, Vol. 51 ›› Issue (1): 55-58.doi: 10.3760/cma.j.cn371439-20230627-00007

• 综述 • 上一篇    下一篇

乳房微生物群与乳腺癌:现状与未来

顾花艳, 朱腾, 郭贵龙()   

  1. 温州医科大学附属第一医院乳腺外科,温州 325000
  • 收稿日期:2023-06-27 修回日期:2023-08-20 出版日期:2024-01-08 发布日期:2024-01-23
  • 通讯作者: 郭贵龙 E-mail:guoguilong@sina.com

Breast microbiota and breast cancer: present and future

Gu Huayan, Zhu Teng, Guo Guilong()   

  1. Department of Breast Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
  • Received:2023-06-27 Revised:2023-08-20 Online:2024-01-08 Published:2024-01-23
  • Contact: Guo Guilong E-mail:guoguilong@sina.com

摘要:

近年来研究发现,乳腺癌组织与正常乳房组织之间存在不同的乳房微生物群。乳房微生物群与乳腺癌的发生、发展有着密切关系,其作用机制包括影响雌激素水平、脂质代谢、免疫调节和炎症反应等。调整饮食、合理使用抗生素及口服益生菌等可调节乳房微生物群,是预防和治疗乳腺癌的新方向。

关键词: 乳腺肿瘤, 微生物群, 肿瘤微环境, 雌激素类

Abstract:

In recent years, studies have found that breast microbiota differs between breast cancer tissue and normal breast tissue. Breast microbiota is closely related to the occurrence and development of breast cancer, and its mechanism includes affecting estrogen levels, lipid metabolism, immune regulation, and inflammatory response. Adjusting diet, rational use of antibiotics and oral probiotics can regulate breast microbiota, which is a new direction for the prevention and treatment of breast cancer.

Key words: Breast neoplasms, Microbiota, Tumor microenvironment, Estrogens