Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (11): 863-865.doi: 10.3760/cma.j.issn.1673422X.2015.11.018

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Expression and role of miRNA375 in digestive system tumors

Chen Zheng, Liu Xiaofeng, Dong Qianqian, Ma Shulin.   

  1. Department of Gastroenterology, General Hospital of Ji′nan Military Commend, Ji′nan 250000, China
  • Online:2015-11-08 Published:2015-09-30
  • Contact: Liu Xiaofeng E-mail:liuxf0531@126.com

Abstract: microRNA (miRNA) plays an important role in biological processes via regulating gene expression in the level of posttranscription. Increasing number of studies reveal that miR375 is downregulated in digestive system tumors, and is related to tumorigenesis. Overexpression of miR375 can inhibit growth and metastasis of tumors through repressing the expression of target genes.

Key words: MicroRNAs, Digestive system neoplasms, Neoplasm metastasis