Drug treatment advances towards metastatic biliary tract cancer

doi:10.3760/cma.j.cn371439-20200304-00104

Abstract

Abstract:

The median overall survival is shorter than 1 year and chemotherapy is still the main treatment for patients with metastatic biliary tract cancer (BTC). Over the recent years, novel molecular targeted therapy and immunotherapy have been extensively tested in this disease. Among them, fibroblast growth factor receptors inhibitors, anti-vasculature therapy and c-Met inhibitors and other new drugs have achieved encouraging curative effect in the treatment of metastatic BTC. Meanwhile, immune checkpoint inhibitors and bifunctional immune agents hold great promise for this type of cancers. Some ongoing phase Ⅲ trials may change the clinical status and improve the outcome for patients with metastatic BTC.

Key words: Biliary tract neoplasms, Molecular targeted therapy, Immunotherapy, Survivorship

Liu Xiaojun, Li Shuping, Wang Wei. Drug treatment advances towards metastatic biliary tract cancer[J]. Journal of International Oncology, 2020, 47(11): 700-704.

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