Mechanism of angiopoietinlike protein 4 in digestive system neoplasms

doi:10.3760/cma.j.issn.1673-422X.2018.06.013

Abstract

Abstract: Angiopoietinlike protein (ANGPTL) 4 is involved in the regulation of multiple tumor growth and metabolism pathways and plays a multifunctional role in many aspects of tumorigenesis such as growth, metastasis, apoptosis, angiogenesis and tumor microenvironment. As one of the members of ANGPTL family, it is confirmed that ANGPTL4 both has a tumorpromoting and tumorinhibiting effect on digestive system neoplasms in recent years. This dual role may be related to its involvement in regulating different tumor signaling pathways. ANGPTL4 is expected to be a new target for diagnosis and treatment of digestive system neoplasms.

Key words: Digestive system neoplasms, Angiopoietin like protein 4, Mechanism

Zhou Shuaiyang, Gong Weijuan, Xiao Weiming. Mechanism of angiopoietinlike protein 4 in digestive system neoplasms[J]. Journal of International Oncology, 2018, 45(6): 371-374.

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