CDX2 and gastrointestinal neoplasms

doi:10.3760/cma.j.cn371439-20201118-00072

Abstract

Abstract:

Caudal type homeobox transcription factor 2 (CDX2) is an enteric-specific nuclear transcription factor, which is mainly expressed in the small intestine and colorectum and not expressed in normal gastric mucosa. CDX2 is involved in the occurrence, development, invasion and metastasis of gastrointestinal tumors, and its expression state is related to the clinicopathological characteristics and prognosis of patients with gastrointestinal tumors. It is expected to provide a new idea for the diagnosis and treatment of gastrointestinal tumors by further studying the mechanism of CDX2 involvement in tumor genesis and development and its relationship with clinicopathological features and prognosis.

Key words: CDX2 transcription factor, Digestive system neoplasms, Intestinal metaplasia

Ju Xinyue, Hu Chunmei, Zhao Yue, Tang Yan. CDX2 and gastrointestinal neoplasms[J]. Journal of International Oncology, 2021, 48(6): 374-376.

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