Journal of International Oncology ›› 2021, Vol. 48 ›› Issue (4): 216-219.doi: 10.3760/cma.j.cn371439-20201012-00043

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Relationship between CDCA8 and tumor progression as well as that between CDCA8 and stemness maintenance of stem cells

Wei Yongjian1, Hu Jinjing2, Li Xun1,2,3()   

  1. 1First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China
    2Gansu Provincial Key Laboratory of Biological Therapy and Regenerative Medicine Transformation, Lanzhou 730000, China
    3Department of General Surgery, First Hospital of Lanzhou University, Medical College of Lanzhou University Trauma Prevention and Treatment Center, Gansu Provincial Research Institute of Hepato-Pancreato-Biliary Surgery, Lanzhou 730000, China
  • Received:2020-10-12 Revised:2020-12-25 Online:2021-04-08 Published:2021-06-18
  • Contact: Li Xun E-mail:lxdr21@126.com
  • Supported by:
    National Natural Science Foundation of China(31570509);Gansu Provincial Science and Technology Plan Project of China(18JR2TA018);Gansu Provincial Major Science and Technology Project of China(1602FKDA001);Gansu Provincial Innovation Capability Improvement Project of Colleges and Universities(2019B-003);"Central Universities Basic Scientific Research Service Fees" of Lanzhou University(lzujbky-2019-kb21);"Central Universities Basic Scientific Research Service Fees" of Lanzhou University(lzujbky-2020-kb22)

Abstract:

Cell division cycle associated 8 (CDCA8) is involved in the accurate regulation of cell division cycle. The expression change of CDCA8 can affect the progression of many kinds of tumors as well as the prognosis of patients. In recent years, studies have suggested that CDCA8 may play an important role in maintaining the stemness of cancer stem cells. Exploring the mechanism of CDCA8 affecting tumor is of great significance for the diagnosis and treatment of tumors.

Key words: Neoplasms, Neoplastic stem cells, Cell division cycle associated 8, Mechanism