Role of tumor microenvironment in tumor drug resistance

doi:10.3760/cma.j.cn371439-20210517-00107

Abstract

Abstract:

Tumor microenvironments (TMEs) are closely related to tumor resistance. TMEs are divided into cellular components and acellular components. The cellular components include tumor-associated macrophages, tumor-associated fibroblasts, mesenchymal stem cells, etc., which can enhance tumor resistance through recruitment and secretion of a variety of protective cytokines; acellular components such as extracellular matrix, hypoxia and acidification, etc., can mediate drug resistance by constructing physical barriers, affecting tumor cell growth and metabolism. Studying the mechanisms of TME-mediated drug resistance and reshaping TMEs can provide new strategies for anti-tumor therapy.

Key words: Tumor microenvironment, Drug resistance, Stromal cells, Acellular component

Fu Weida, Chen Mengjiao, Guo Guilong, Zheng Shurong. Role of tumor microenvironment in tumor drug resistance[J]. Journal of International Oncology, 2021, 48(9): 553-556.

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