Research advances of Mfn2 in tumor

doi:10.3760/cma.j.cn371439-20200212-00008

Abstract

Abstract:

Mitofusin 2 (Mfn2) plays an important role in the process of mitochondrial fusion, and is involved in regulating mitochondrial function and morphological changes. Studies have found that Mfn2 has a tumor suppressor effect in a variety of malignant tumors and their cell lines, including cervical cancer, hepatocellular cancer, pancreatic cancer, breast cancer, and bladder cancer. The difference in the expression of Mfn2 in malignant tumor tissues suggests that Mfn2 may play an important role in the proliferation, apoptosis, invasion and migration of malignant tumor cells. As a cancer-related gene, Mfn2 provides new ideas for gene therapy of malignant tumors.

Key words: Neoplasms, Mfn2, Cell proliferation, Cell apoptosis, Cell invasion

Wei Mengyu, Ma Li. Research advances of Mfn2 in tumor[J]. Journal of International Oncology, 2021, 48(1): 45-47.

References 25

[1]	Pang G, Xie Q, Yao J. Mitofusin 2 inhibits bladder cancer cell proli-feration and invasion via the Wnt/β-catenin pathway[J]. Oncol Lett, 2019,18(3):2434-2442. DOI: 10.3892/ol.2019.10570. pmid: 31402945
[2]	黄健, 卢博, 邹前, 等. Mfn2调节线粒体自噬[J]. 吉林医药学院学报, 2018,39(1):59-61.
[3]	Xu K, Chen G, Li X, et al. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling[J]. Sci Rep, 2017,7:41718. DOI: 10.1038/srep41718. doi: 10.1038/srep41718 pmid: 28176801
[4]	Samanas NB, Engelhart EA, Hoppins S. Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax[J]. Life Sci Alliance, 2020,3(5):e201900527. DOI: 10.26508/lsa.201900527. pmid: 32245838
[5]	Han J, Liu J, Zhou Q, et al. Single nucleotide polymorphisms (SNPs) genotyping reveals that Mfn2 polymorphisms are associated with thoracic aortic dissection in Han Chinese population[J]. Med Sci Monit, 2019,25:2419-2428. DOI: 10.12659/MSM.915272. doi: 10.12659/MSM.915272 pmid: 30940795
[6]	Yang Y, Xue LJ, Xue X, et al. MFN2 ameliorates cell apoptosis in a cellular model of Parkinson's disease induced by rotenone[J]. Exp Ther Med, 2018,16(4):3680-3685. DOI: 10.3892/ETM.2018.6595. pmid: 30233726
[7]	Chandhok G, Lazarou M, Neumann B. Structure, function, and re-gulation of mitofusin-2 in health and disease[J]. Biol Rev Camb Philos Soc, 2018,93(2):933-949. DOI: 10.1111/brv.12378. doi: 10.1111/brv.12378 pmid: 29068134
[8]	Ma L, Liu Y, Geng C, et al. Estrogen receptor β inhibits estradiol-induced proliferation and migration of MCF-7 cells through regulation of mitofusin 2[J]. Int J Oncol, 2013,42(6):1993-2000. DOI: 10.3892/ijo.2013.1903. doi: 10.3892/ijo.2013.1903 pmid: 23588792
[9]	Van Nieuwenhuysen E, Busschaert P, Laenen A, et al. Loss of 1p36.33 frequent in low-grade serous ovarian cancer[J]. Neoplasia, 2019,21(6):582-590. DOI: 10.1016/j.neo.2019.03.014.
[10]	Huang XB, Song KJ, Chen GB, et al. Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration ad invasion by regulating MAPK pathway[J]. Cancer Bio Ther, 2020,13:1-11. DOI: 10.1080/15384047.2020.1824513.
[11]	Liu X, Sun J, Yuan P, et al. Mfn2 inhibits proliferation and cell-cycle in HeLa cells via Ras-NF-κB signal pathway[J]. Cancer Cell Int, 2019,19:197. DOI: 10.1186/s12935-019-0916-9. doi: 10.1186/s12935-019-0916-9 pmid: 31384172
[12]	Wang W, Liu X, Guo X, et al. Mitofusin-2 triggers cervical carcinoma cell HeLa apoptosis via mitochondrial pathway in mouse model[J]. Cell Physiol Biochem, 2018,46(1):69-81. DOI: 10.1159/000488410. doi: 10.1159/000488410 pmid: 29587277
[13]	Pang CL, Thierry F. Human papillomavirus proteins as prospective therapeutic targets[J]. Microb Pathog, 2013,58:55-65. DOI: 10.1016/j.micpath.2012.11.002. pmid: 23164805
[14]	牛亚倩, 常钰玲, 刘芳, 等. 肝细胞癌中微小RNA对mTOR信号通路的调控作用[J]. 国际肿瘤学杂志, 2019,46(10):624-626. DOI: 10.3760/cma.j.issn.1673-422X.2019.10.012.
[15]	Feng X, Zhu K, Liu J, et al. The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy[J]. Onco Targets Ther, 2016,9:3213-3221. DOI: 10.2147/OTT.S98322. pmid: 27313467
[16]	Wang W, Xie Q, Zhou X, et al. Mitofusin-2 triggers mitochondria Ca²⁺ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells[J]. Cancer Lett, 2015,358(1):47-58. DOI: 10.1016/j.canlet.2014.12.025. pmid: 25541060
[17]	Xu Z, Pothula SP, Wilson JS, et al. Pancreatic cancer and its stroma: a conspiracy theory[J]. World J Gastroenterol, 2014,20(32):11216-11229. DOI: 10.3748/wjg.v20.i32.11216. doi: 10.3748/wjg.v20.i32.11216 pmid: 25170206
[18]	Lin QJ, Yang F, Jin C, et al. Current status and progress of pancreatic cancer in China[J]. World J Gastroenterol, 2015,21(26):7988-8003. DOI: 10.3748/wjg.v21.i26.7988. doi: 10.3748/wjg.v21.i26.7988 pmid: 26185370
[19]	Pan L, Zhou L, Yin W, et al. miR-125a induces apoptosis, meta-bolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission[J]. Int J Oncol, 2018,53(1):124-136. DOI: 10.3892/ijo.2018.4380. pmid: 29749475
[20]	Xue R, Meng Q, Lu D, et al. Mitofusin2 induces cell autophagy of pancreatic cancer through inhibiting the PI3K/Akt/mTOR signaling pathway[J]. Oxid Med Cell Longev, 2018,2018:2798070. DOI: 10.1155/2018/2798070. doi: 10.1155/2018/2798070 pmid: 30046371
[21]	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017,67(1):7-30. DOI: 10.3322/caac.21387. pmid: 28055103
[22]	Ma LI, Chang Y, Yu L, et al. Pro-apoptotic and anti-proliferative effects of mitofusin-2 via PI3K/Akt signaling in breast cancer cells[J]. Oncol Lett, 2015,10(6):3816-3822. DOI: 10.3892/ol.2015.3748. doi: 10.3892/ol.2015.3748
[23]	Zhang J, Sun L, Li W, et al. Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy[J]. Biomed Pharmacother, 2019,114:108844. DOI: 10.1016/j.biopha.2019.108844. pmid: 30981108
[24]	Cheng X, Zhou D, Wei J, et al. Cell-cycle arrest at G₂/M and proliferation inhibition by adenovirus-expressed mitofusin-2 gene in human colorectal cancer cell lines[J]. Neoplasma, 2013,60(6):620-626. DOI: 10.4149/neo_2013_080. pmid: 23906296
[25]	Fang CL, Sun DP, Chen HK, et al. Overexpression of mitochondrial GTPase MFN2 represents a negative prognostic marker in human gastric cancer and its inhibition exerts anti-cancer effects[J]. J Cancer, 2017,8(7):1153-1161. DOI: 10.7150/jca.17986. doi: 10.7150/jca.17986 pmid: 28607589