Role of antibiotics in tumor development and immunotherapy

doi:10.3760/cma.j.cn371439-20200423-00009

Abstract

Abstract:

In recent years, immunotherapy with immune checkpoint inhibitor (ICI) as the representative drug has become an important treatment method for advanced malignant tumors. Preclinical studies have found that disorders of the gut microbiota can reduce the clinical benefit of patients treated with ICI. The latest data indicate that antibiotics may further affect the occurrence and development of tumors and the efficacy of immunotherapy by changing the abundance and composition of intestinal microbiota. To sum up the role of anti-biotics in the immunotherapy of advanced malignant tumor may provide a new idea for the optimization of treatment strategies for patients with advanced cancer.

Key words: Anti-bacterial agents, Immunotherapy, Microbiota, Prognosis

Yang Mengxue, Yuan Man, Tong Jiandong, Yan Xuebing. Role of antibiotics in tumor development and immunotherapy[J]. Journal of International Oncology, 2021, 48(1): 48-51.

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