Research progress of hyperprogressive disease after immunotherapy

doi:10.3760/cma.j.cn371439-20200118-00111

Abstract

Abstract:

Hyperprogressive disease is a new pattern of progression recently described in patients with cancer treated with immunotherapeutics, which are represented by programmed cell death-1 and programmed cell death ligand-1 (PD-1/PD-L1) inhibitors. Hyperprogressive manifests as after anti-PD-1/PD-L1 immunotherapy, the patient's condition worsens and tumor grows faster. At present, on account of its unclear mechanism and a lack of effective treatment methods, the incidence of hyperprogressive is high and the prognosis of hyperprogressive patients is poor.

Key words: Immunotherapy, Hyperprogression, PD-1/PD-L1

Xu Yangtao, Chen Biao, He Xiaoqin, Xu Ximing. Research progress of hyperprogressive disease after immunotherapy[J]. Journal of International Oncology, 2020, 47(12): 737-740.

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