Molecular targeted therapy of triple-negative breast cancer

doi:10.3760/cma.j.issn.1673-422X.2014.09.007

Abstract

Abstract: Treatment options are limited for triple negative breast cancer (TNBC) since endocrinotherapy and targeted therapy that aims directly at human epidermal growth factor receptor-2 (HER-2) are ineffective. As such, in addition to surgical treatment, the mainstay of treatment of TNBC is systemic cytotoxic chemotherapy. The targeted therapy of TNBC is becoming a research hotspot because of traditional chemotherapy curative effect is not good enough. A large number of clinical trials have found that patients with TNBC can get benefits from targeted molecular strategies including polyadenosine diphosphate glucose pyrophospheralase-ribose polymerase-1 (PARP-1) inhibitor and epidermal growth factor receptor (EGFR) inhibitor.

Key words: Breast neoplasms, Antineoplastic agents, Molecular targeted therapy

Gong Liya, Chen Hongfeng. Molecular targeted therapy of triple-negative breast cancer[J]. Journal of International Oncology, 2014, 41(8): 662-665.

References

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