Abstract: Lysyal oxidase (LOX), a cooper dependent monoamine oxidase, can stabilize the extracellular matrix and is closely related to the tumor cell differentiation, vicious transformation and invasiveness. LOX is secreted into extracellular, and it is resolved into a small fragment by sol protease, which is lysyal oxidase propeptide (LOX-PP). According to research, LOX-PP has its own structure and physiological functions,which can inhibit the growth of tumor cells. LOX-PP also plays a significant role in the generation and progression of tumor cells. LOX-PP is the hot spot of research currently, and it’s likely to be a new therapeutic target.

Key words: Protein-lysine 6-oxidase, Neoplasms, Genes, tumor suppressor