Abstract: CXCL12, also known as stromal cell-derived factor 1, is a member of the CXC family, which locates on the 10th chromosome and produces by the stromal cells. It is known that CXCR4 and CXCR7 are the two receptors of chemokine CXCL12. Many studies show that the chemokine CXCL12 plays an important role in cancer progression, including proliferation, metastasis and angiogenesis. Therefore, the chemokine CXCL12 is expected to become a novel target for the gene therapy of cancer.

Key words: Neoplasms, Cell proliferation, Neoplasm metastasis, Neovascularization, pathologic