Abstract: Adrenomedullin (ADM) has wide distribution in the body and has many biological effects, which participates in many physiological and pathological processes. What’s more, it is closely related to the degree of malignancy, prognosis and metastasis of tumors. ADM has different effects on different types of cells via one or more signal pathways, so that can product various effects. It also provides a new treatment strategy for preventing or slowing the progress of the cancer.

Key words: Adrenomedullin, Cell movement, Endothelial cells, Neoplasms