Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (3): 231-234.doi: 10.3760/cma.j.issn.1673422X.2017.03.019

Previous Articles     Next Articles

Research progress of the competing endogenous RNA in primary hepatocellular carcinoma

He Xiaoqin, Xu Ximing   

  1. Cancer Center, Renmin Hospital of WuhanUniversity, Wuhan 430060, China
  • Online:2017-03-08 Published:2017-02-28
  • Contact: Xu Ximing E-mail:doctorxu120@aliyun.com

Abstract: Competing endogenous RNAs (ceRNAs) transcripts can communicate with microRNAs (miRNAs) through competitively binding the common miRNA response elements (MREs), which remove or decrease the repression of target genes of miRNAs. The present studies indicate that a large amount of genes, serving as ceRNAs, can promote or inhibit the occurrence of liver cancer by competing the binding site of same genes that can promote or suppress tumorigenesis.

Key words: Liver neoplasms, MicroRNAs, Long noncoding RNA