Journal of International Oncology ›› 2024, Vol. 51 ›› Issue (7): 458-463.doi: 10.3760/cma.j.cn371439-20231130-00075

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Tumor-infiltrating immune cells from a single-cell perspective

Du Qilian, Hu Qinyong()   

  1. Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Received:2023-11-30 Revised:2024-04-07 Online:2024-07-08 Published:2024-08-14
  • Contact: Hu Qinyong, Email: rm001223@whu.edu.cn
  • Supported by:
    Wuhan University 2021 Medical Department Teaching and Research Project(2021026)

Abstract:

Immune microenvironment is closely related to the treatment and prognosis of tumors. Tumor-infiltrating immune cells exhibit significant heterogeneity in different stages of tumors. Single-cell RNA sequencing (scRNA-seq) is widely used in the study of various tumor microenvironment to analyze the biological behavior, mechanisms, and relationship between cells and the body at the single-cell level. The results showed that using scRNA-seq can deeply understand the immune characteristics of tumor-infiltrating immune cells.

Key words: Single-cell analysis, Lymphocytes, Myeloid cells, Neoplasms