Research progress of immune checkpoint agonist for solid tumor treatments

doi:10.3760/cma.j.cn371439-20220726-00058

Abstract

Abstract:

Immune checkpoint consists of inhibitory and stimulatory molecules. Drugs blocking inhibitory checkpoint programmed cell death receptor-1 （PD-1） and cytotoxic T lymphocyte-associated molecule-4 （CTLA-4） are currently utilized for wide variety of human cancers. Agonists of stimulatory checkpoints such as GITR， OX40， 4-1BB， ICOS， CD40 and STING are undergoing critical clinical trials. Immune checkpoint agonists that affect stimulatory checkpoint molecules develop rapidly， and immune agonist antibodies thus represent an important approach for solid tumor treatments.

Key words: Neoplasms, Stimulatory checkpoint molecules, Immune agonist antibody, Therapy

Yue Hongyun, Zhang Baihong. Research progress of immune checkpoint agonist for solid tumor treatments[J]. Journal of International Oncology, 2023, 50(5): 290-293.

Figures/Tables 1

References 29

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受体和配体	作用机制	试验阶段	代表药物
GITR-GITRL	促进Teff细胞激活和增殖，减少Treg细胞	Ⅱ期	TRX518、MK-1248^[5,7]
OX40-OX40L	促进Teff细胞和记忆T细胞存活	Ⅱ期	MEDI6469^[9]
4-1BB-4-1BBL	促进T细胞增殖和提高线粒体功能	Ⅰ期	乌托鲁单抗、乌瑞芦单抗^[11-12]
ICOS-ICOSL	促进TCR共刺激和Treg细胞激活	Ⅰ期	GSK3359609^[17]
CD40-CD40L	促进T细胞激活和浸润	Ⅰ期	CP-870893、Sotigalimab^[21-22]
cGAS-STING	提高抗肿瘤免疫反应	临床前研究	MSA-2^[26-27]