Application of circulating tumor DNA in targeted therapy and immunotherapy of metastatic melanoma

doi:10.3760/cma.j.cn371439-20191223-00041

Abstract

Abstract:

Targeted therapy and immunotherapy are important methods for the treatment of metastatic melanoma, but monitoring the patient's disease progress and treatment response during the treatment is the key to accurate treatment and personalized treatment.Circulating tumor DNA (ctDNA) as a non-invasive "liquid biopsy" method, due to its high sensitivity and specificity for gene mutations, and the advantages of being qualitative, quantitative and traceable, which has shown great application value in monitoring metastatic melanoma progression, evaluating efficacy, and predicting prognosis during targeted therapy and immuno-therapy.

Key words: Melanoma, Molecular targeted therapy, Circulating tumor DNA, Immunotherapy

Du Mingli, Li Guixiang, Wu Wenjuan, Zhao Lei. Application of circulating tumor DNA in targeted therapy and immunotherapy of metastatic melanoma[J]. Journal of International Oncology, 2020, 47(6): 381-384.

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