骨髓微环境与白血病细胞分化

doi:10.3760/cma.j.cn371439-20200619-00038

国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (3): 189-192.doi: 10.3760/cma.j.cn371439-20200619-00038

• 综述 • 上一篇

骨髓微环境与白血病细胞分化

陈曦, 母丹, 严钦, 刘文君^*()

西南医科大学附属医院儿科儿童血液与肿瘤PI实验室四川省出生缺陷临床医学研究中心,泸州 646000

收稿日期:2020-06-19 修回日期:2020-09-17 出版日期:2021-03-08 发布日期:2021-03-25
通讯作者: 刘文君 E-mail:lwjlyfy@qq.com
基金资助:
四川省应用基础研究(2019YJ0690);四川省重大科技专项(2019YFS0531);泸州市科技计划(2019-RCM-98);泸州市科技计划(2019-RCM-96)

Bone marrow microenvironment and differentiation of leukemia cells

Chen Xi, Mu Dan, Yan Qin, Liu Wenjun^*()

Department of Pediatric, Affiliated Hospital of Southwest Medical University, PI Research Laboratory of Children's Hematology and Oncology, Sichuan Clinical Research Center for Birth Defects, Luzhou 646000, China

Received:2020-06-19 Revised:2020-09-17 Online:2021-03-08 Published:2021-03-25
Contact: Liu Wenjun E-mail:lwjlyfy@qq.com
Supported by:
Sichuan Applied Basic Research(2019YJ0690);Major Science and Technology Project of Sichuan Province(2019YFS0531);Luzhou Science and Technology Project of China(2019-RCM-98);Luzhou Science and Technology Project of China(2019-RCM-96)

摘要/Abstract

摘要：

骨髓微环境(BMM)是白血病细胞赖以生存的环境,包含有干细胞、骨髓基质细胞以及丰富的细胞因子,可以调控白血病细胞分化、增殖等活动。BMM对白血病细胞分化的调控是一个复杂的过程,可以作用于不同的靶点和信号通路,主要包括低氧诱导因子、整合素、Notch及Wnt/β-catenin等信号通路途径。通过研究BMM与白血病细胞分化的关系,找到诱导白血病分化的通路和靶点将为白血病的治疗找到新方向。

关键词: 骨髓, 白血病, 细胞分化, 微环境

Abstract:

Bone marrow microenvironment (BMM) is the environment on which leukemia cells depend. It contains stem cells, bone marrow stromal cells, and abundant cytokines, which can regulate the differentiation and proliferation of leukemia cells. The regulation of BMM on the differentiation of leukemia cells is a complex process that can act on different targets and signaling pathways. It mainly includes hypoxia-inducible factor, integrins, Notch, and Wnt/β-catenin signal pathways. The study of relationship between BMM and leukemia cell differentiation can help to find pathways and targets that induce leukemia differentiation which will find new directions for the treatment of leukemia.

Key words: Bone marrow, Leukemia, Cell differentiation, Microenvironment

陈曦, 母丹, 严钦, 刘文君. 骨髓微环境与白血病细胞分化[J]. 国际肿瘤学杂志, 2021, 48(3): 189-192.

Chen Xi, Mu Dan, Yan Qin, Liu Wenjun. Bone marrow microenvironment and differentiation of leukemia cells[J]. Journal of International Oncology, 2021, 48(3): 189-192.

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骨髓微环境与白血病细胞分化

Bone marrow microenvironment and differentiation of leukemia cells

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