国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (3): 218-220.doi: 10.3760/cma.j.issn.1673422X.2015.03.015

• 综述 • 上一篇    下一篇

  幽门螺杆菌致胃癌发生的作用机制

吴来,侯云修   

  1. 256600  山东省滨州医学院附属医院消化内科
  • 出版日期:2015-03-08 发布日期:2015-01-29
  • 通讯作者: 侯云修， Email:byfytjzx@163.com E-mail:byfytjzx@163.com

Mechanisms of helicobacter pylori on the occurrence of gastric cancer

Wu Lai, Hou Yunxiu   

  1. Department of Gastroenterology, Binzhou Medical School Affiliated Hospital Shandong, BinZhou 256600, China
  • Online:2015-03-08 Published:2015-01-29
  • Contact: Hou Yunxiu E-mail:byfytjzx@163.com

PDF

1432

摘要： 幽门螺杆菌是引起胃癌的病因之一。幽门螺杆菌能引起胃黏膜炎症因子聚集，损伤胃黏膜；并通过多种途径激活上皮细胞内多个致瘤通路，包括磷脂酰肌醇3激酶（PI3K）途径、Wntβ连环蛋白和环氧化合酶2(COX2)前列腺素E2抗体（PGE2）途径等，从而改变胃干细胞的微环境并扰乱胃干细胞的分化和增殖，使正常胃干细胞演变为癌症干细胞。

关键词: 干细胞, 螺杆菌, 幽门, 肿瘤微环境

Abstract: Helicobacter pylori is one of causes of gastric cancer. It can cause mucosal inflammation cytokines aggregation, gastric mucosal damage; and through a variety of ways to activate epithelial cells multiple oncogenic pathways, including phosphatidylinositol 3 kinase (PI3K) pathway, Wntβcatenin and epoxidized synthase 2 (COX2)prostaglandin E2 antibody (PGE2) pathway, so as to change the gastric stem cell microenvironment and disrupt the gastric stem cell differentiation and proliferation, making the normal gastric stem cells evolved into cancer stem cells.

Key words: Stem cells, Helicobacter pylori, Tumor microenvironment