Table of Content

24 December 2014, Volume 41 Issue 12 Previous Issue    Next Issue

For Selected:

Download Citations EndNote Reference Manager ProCite BibTeX RefWorks

Toggle Thumbnails

MicroRNAs and epithelial mesenchymal transition in cancer HAN Xue, LI Man 2014, 41 (12):  881-884.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.001 Abstract ( 355 )   PDF (744KB) ( 1293 )   Save In recent years, a lot of researches have shown microRNA (miRNA) involved in every link of epithelialmesenchymal transition(EMT) regulation process through a variety of signaling pathways in tumor; even the same kind of miRNA  plays significantly different roles in different tumors, inducing great significance to guide clinic. References | Related Articles | Metrics

The role of microRNAs in breast cancer stem cells MAO Chang-Fei, WU Jian-Zhong, TANG Jin-Hai 2014, 41 (12):  884-887.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.002 Abstract ( 350 )   PDF (666KB) ( 1359 )   Save The role of microRNAs in breast cancer stem cellsMao Changfei, Wu Jianzhong, Tang Jinhai. Corresponding author:【Abstract】Cancer stem cells are a kind of cancer cell group with the ability of selfrenewal and various diferentiation potentials. Recent studies have implicated that they play a significant role in tumor formation, metastasis, resistance to anticancer therapies and cancer recurrence. Many studies show that microRNAs are involved in the maintenance, growth and behavior of breast cancer stem cells(BCSCs), paving a new way for diagnosis, prognosis and therapy of breast cancer. References | Related Articles | Metrics

Research progress of miR-451 in tumor 南Yang , ZHONG Yue 2014, 41 (12):  887-890.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.003 Abstract ( 392 )   PDF (667KB) ( 1189 )   Save MicroRNA451(miR451) is significantly lowly expressed in glioma, gastric cancer, colorectal cancer, liver cancer and other tumor tissues. Upregulation of miR451 can significantly inhibit tumor cell proliferation，invasion and metastasis as well as increasing tumor cell apoptosis and improving radiotherapy and chemotherapy sensitivity and other biological effects. References | Related Articles | Metrics

Role of zincfinger protein X-linked in the development of neoplasms YAN Lei-Lei, PENG Jia-Yuan, WANG Yu 2014, 41 (12):  890-893.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.004 Abstract ( 292 )   PDF (671KB) ( 1270 )   Save Zincfinger protein Xlinked is a member of zinc finger protein family. Its abnormal expression has been found in a variety of stem cells and malignant tumor cells. Recent studies have shown that it plays an important role in stem cell selfrenewal and cancer cell proliferation, apoptosis and migration. References | Related Articles | Metrics

Roles of transforming growth factor-β1 in cancer stem cells MA Yu-Lei, LI Hai-Yuan, ZHOU Chuan, ZHOU Feng-Hai, 吕Hai-Di , WANG Shi-Guang 2014, 41 (12):  893-895.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.005 Abstract ( 404 )   PDF (663KB) ( 1124 )   Save Tumor stem cells are responsible for metastasis and relapse of cancer. Transforming growth factorβ1 (TGFβ1) plays an important role in the proliferation and differentiation of tumor stem cells. In many cancers such as breast carcinoma, hepatocellular carcinoma, pancreatic carcinoma, lung carcinoma, glioma and gallbladder carcinoma, the epithelialmesenchymal transition (EMT) induced by TGFβ1 can inhibit proliferation of cancer cell, enrich tumor stem cells and increase invasive capability and drug resistance of cancer. References | Related Articles | Metrics

Roles of transforming growth factor-β1 in cancer stem cells MA Yu-Lei, LI Hai-Yuan, ZHOU Chuan, ZHOU Feng-Hai,LV Hai-Di , WANG Shi-Guang 2014, 41 (12):  893-895.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.005 Abstract ( 44 )   PDF (663KB) ( 1102 )   Save Tumor stem cells are responsible for metastasis and relapse of cancer. Transforming growth factorβ1 (TGFβ1) plays an important role in the proliferation and differentiation of tumor stem cells. In many cancers such as breast carcinoma, hepatocellular carcinoma, pancreatic carcinoma, lung carcinoma, glioma and gallbladder carcinoma, the epithelialmesenchymal transition (EMT) induced by TGFβ1 can inhibit proliferation of cancer cell, enrich tumor stem cells and increase invasive capability and drug resistance of cancer. References | Related Articles | Metrics

Self-renewal mechanism of cancer stem cells WANG Tong, QI Xiao-Fei, ZHANG Ri 2014, 41 (12):  896-898.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.006 Abstract ( 404 )   PDF (657KB) ( 1987 )   Save Cancer stem cells comprise a subpopulation with the capacity of selfrenewal,  selfdifferentiation and high tumorigenicity. Cancerogenesis, development, relapse and therapeutic resistance are closely related with these cells. The most important characteristics of these cells are the ability to selfrenew. So insight into the regulating mechanism of selfrenewal in cancer stem cells will be important for the development of novel molecular agents targeted the cancer stem cells. References | Related Articles | Metrics

Progression of brain tumor stem cell markers WU Bin, XIA Liang 2014, 41 (12):  899-901.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.007 Abstract ( 378 )   PDF (658KB) ( 1199 )   Save Brain tumor stem cells(BTSCs) play a key role in tumorigenesis and tumor development.There are a group of special markers in the surface of brain tumor stem cells, which can sorts stem cells, precursor cells and cancer stem cells. In recent years, the studies of CD133, Nestin, highmobility group A1, A2B5 have made some breakthroughs. References | Related Articles | Metrics

Research advance on vasculogenic mimicry in glioma DENG Jun, GUO Yu-Hong, GUO Geng 2014, 41 (12):  902-905.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.008 Abstract ( 427 )   PDF (670KB) ( 1346 )   Save Vasculogenic mimicry (VM) is a pattern of neoplasm cells, which achieve their blood supplements through deformation and simulating capillary channels. Cumulative studies show that the formation of VM in glioma have a close relation with the glioma stem cells. In addition, some molecules such as microRNA, epithelial cell kinaseA2, vascular endothelial cadherin, transforming growth factorβ, vascular endothelial growth factor receptor2 and galectin1 play important roles in the forming process of vasculogenic mimicry. Recently, it is found that VM is associated with the poor prognosis of patients with glioma and anti angiogenesis drug efficacy. So the research on VM about the discovery, formation mechanism, prognostic impact and the clinical significance will provide an opportunity for diagnosis and therapy of glioma in early stage. References | Related Articles | Metrics

Chronic inflammation in the promotion of lung carcinogenesis YANG Rui-Xu, DENG Jiong 2014, 41 (12):  906-909.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.009 Abstract ( 401 )   PDF (666KB) ( 1548 )   Save Chronic inflammation is proved to play an important role in promoting carcinogenesis. Many factors in inflammatory microenvironment, such as inflammatory immune cells, pro-inflammatory cytokines, inflammatory mediators, and aberrantly activated transcription factors of proinflammatory pathway (NF-κB, STAT3), have been found to provide a microenvironment for lung neoplastic processes, and promote the lung carcinogenesis. On the other hand, many antiinflammatory agents have been shown having inhibitory effects on lung tumorigenicity. With further understanding of the molecular links between inflammation and lung tumorigenesis, antiinflammation would provide alternative strategies for prevention and therapy of lung cancer. References | Related Articles | Metrics

Research progress of ERCC1 in non-small cell lung cancer based on the platinum drugs LIU Zhi-Bao, ZHANG Jing-Hua 2014, 41 (12):  909-912.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.010 Abstract ( 293 )   PDF (666KB) ( 1320 )   Save Excision repair cross complementing group 1 (ERCC1) gene is an enzyme of the speed limit of DNA repair protein in nucleotide excision repair (NER) pathways.Researches suggest that ERCC1 has been associated with cisplatin resistance in nonsmall cell lung cancer (NSCLC) patients. Thus, ERCC1 gene is a new target in malignant tumor gene therapy research,providing a new approach for the treatment of malignant,especially NSCLC. References | Related Articles | Metrics

Application of image-guided adaptive radiation therapy in lung cancer FANG Jin-Mei, WANG Fan 2014, 41 (12):  912-914.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.011 Abstract ( 440 )   PDF (659KB) ( 1406 )   Save Corresponding author: Adaptive radiotherapy (ART) is the product of excellence technology.  It reschedules, registers according to tumor′s size, shape and alteration of relative position with the surrounding tissue during the treatment. Thereby it raises the accuracy of  the conformal radiotherapy. The technology is gradually being chosen by more and more patients. The technology can increase the rate of local control significantly, while reducing the occurrence of radiationrelated adverse reactions. References | Related Articles | Metrics

Research of hepatocyte nuclear factor 4α in digestive system tumors WANG Juan, HU Zhi-Qian 2014, 41 (12):  915-918.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.012 Abstract ( 468 )   PDF (667KB) ( 1184 )   Save Hepatocyte nuclear factor 4α is a transcription factor of the nuclear hormone receptor superfamily and plays a very important role in the differentiation and development of the digestive system as well as the polarity regulation, which is considered to be a tumor suppressor gene．It also plays a very important role in digestive tumorigenesis , invasion and metastasis of hepatic carcinoma, colon cancer and gastric cancer, which is closely associated with epithelialtomesenchymal transition, the regulation of cell proliferation and wnt signaling pathway. HNF4α expression and its regulation mechanism in the digestive system tumors are now the research focus. References | Related Articles | Metrics

Research progress of SPARC in esophageal cancer HUANG Hai-Bo, ZHAO Yan-Yang, SHU Jun 2014, 41 (12):  918-921.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.013 Abstract ( 402 )   PDF (666KB) ( 1330 )   Save Secreted protein acidic and rich in cysteine (SPARC) is expressed in esophageal cancer abnormally. On the one hand, recent studies show that high SPARC expression is correlated with progression and metastasis of esophageal cancer. On the other hand, high SPARC expression increases chemosensitivity and improves shortterm efficacy in patients. References | Related Articles | Metrics

Research progress of lymph node metastasis in esophageal cancer YING Yin-Yin, XU Ya-Ping, MAO Wei-Min 2014, 41 (12):  921-925.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.014 Abstract ( 619 )   PDF (673KB) ( 1629 )   Save Lymph nodes （LN）are the main parts of the esophageal cancer metastasis, and the current status of LN is the important indicator of prognosis. LN metastasis appears in early stage of esophageal cancer. One side, LN metastasis easily appears in the regions near the tumor and some special areas. On the other side, LN metastasis has the characteristics of wide metastasis and skip metastasis. Therefore, the researches of the pattern of esophageal cancer lymph node metastasis can help to comform the scope of the esophageal cancer lymph node dissection and the target regions of radiotherapy. References | Related Articles | Metrics

Non-surgical treatment of hepatocellular carcinoma LU Guang-Ping 2014, 41 (12):  925-929.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.015 Abstract ( 394 )   PDF (676KB) ( 1286 )   Save Treatment strategies of advanced hepatocellular carcinoma reduce pain, improve quality of life and prolong survival. The latest developments at home and abroad focus on a variety of topical treatments (endovascular treatment, a variety of ablation therapy, radiation therapy) combined with each other and also combined with targeted therapy. In addition, systemic chemotherapy, biological targeting therapy and traditional Chinese medicine have achieved some new progressions. References | Related Articles | Metrics

Mechanism of phytochemicals as anticancer agents in parcreatic carcinoma DANG Jun-Qiang, CHEN Yuan, LIN Wen, LI Chang-Bin 2014, 41 (12):  930-933.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.016 Abstract ( 537 )   PDF (667KB) ( 1314 )   Save Pancreatic cancer remains a devastating disease with a 5year survival rate of less than 5%. Recent advances in diagnostic methods and therapeutic approaches have increased the possibility of improving the existing poorprognosis. Recently, compounds from naturalsources receive ample attention as anticancer agents. Overwhelming in vitro evidence and clinical trials suggest that curcuminn, isothiocyanate, capsaicin, catechin may reduce the incidence of cancer. References | Related Articles | Metrics

Chemotherapy and radiatherapy induced haemorrhagic cystitis: current progress of the treatment YIN Zhuo-Min, YU Hua 2014, 41 (12):  934-937.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.017 Abstract ( 709 )   PDF (664KB) ( 1593 )   Save Haemorrhagic cystitis (HC) is a potentially severe complication, caused by highdose chemotherapeutic drugs or radiation therapy (RT). It is thought that a defect caused by chemotherapeutic drugs in the glycosaminoglycan (GAG) layer may be the first step in HC development. The pathogenesis of RTinduced cystitis originates as a progressive obliteration of the small blood vessels of the bladder wall. Mesna, hyperhydration and continuous bladder irrigation have been shown effective in preventing HC. However, these preventive protocols do not always satisfactorily protect the patient from bladder injury. In recent years, GAGreplenishment therapy and hyperbaric oxygen therapy have gained some evidence exists. Currently, there is a lack of consensus about the best treatment for patients with chemotherapy and radiatherapy induced HC. Therefore, the prevention and treatment of this complication is still the focus at present. References | Related Articles | Metrics

Clinical progress of the standard treatment of cervical cancer BAI Jing 2014, 41 (12):  937-940.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.018 Abstract ( 380 )   PDF (665KB) ( 1377 )   Save In recent years, the efficacy of cervical cancer treatment has been increasing gradually. It has got a basic consensus of the standard treatment mode for most cervical cancer, but further effort should be done to improve the treatment response of locally advanced cervical cancer and recurrent or metastatic cervical cancer. The efect of redical surgery and radiotherpy is the same to early cervical cancer. Concurrent chemoradiotherapy is the standard treatment for patients with locally advanced cervical cancer. Chemotherapy combined with antiangiogenic targeted therapy can improve the survival of patients with recurrent or metastatic cervical cancer, while whether needing new adjuvant therapy or not, it asks for further investigation. References | Related Articles | Metrics

Endostatins combined radiotherapy and chemotherapy in the treatment of advanced non-small cell lung cancer ZHANG Lei, CAO Yong 2014, 41 (12):  941-945.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.019 Abstract ( 324 )   PDF (953KB) ( 1162 )   Save ObjectiveTo preliminary study clinical efficacy and toxicity of endostatin (ES) combined radiotherapy and chemotherapy in advanced nonsmall cell lung cancer (NSCLC), and evaluate its effectiveness and safety. MethodsWe retrospectively reviewed 64 patients with ⅢBⅣ stage NSCLC of Harbin Medical University Cancer Hospital from February 2009 to February 2012.The patients were divided into two groups:chemoradiotherapy group, 39 patients and ES add chemoradiotherapy group, 25 patients. The shortterm effect, the total efficiency, median survival time, progressionfree survival time and diseasefree survival time were compared. ResultsThe total effective rate of chemoradiotherapy group was 76.9%, while the total effective rate of ES add chemotherapy group was 84.0%（χ2=0.47, P=0.492）. Chemoradiotherapy group, compared to ES add chemotherapy group, the median survival time, median progressionfree survival time, median diseasefree survival time were 11.52 months vs 16.51 months (χ2=3.74, P=0.042), 7.32 months vs 10.37 months (χ2=5.32, P=0.025) and 5.21 months vs 7.57 months (χ2=4.56, P=0.035)respectively. The mainly adverse drug reactions were hematologic toxicity and gastrointestinal reactions, but there were no significant differences between the two groups; radiotherapy side effects mainly showed the grade 1 to 2 radiationinduced lung injury and radiation esophagitis (chemotherapy group had one case of grade 3 radiationinduced lung injury), but also had no significant differences between the two groups. ConclusionES combined chemoradiotherapy can achieve a better shortterm clinical efficacy without increasing adverse effects of radiotherapy or  chemotherapy in advanced nonsmall cell lung cancer. References | Related Articles | Metrics

Expression and clinical significance of IMP3 and p16 in cervical carcinoma FENG Yan-Li 2014, 41 (12):  946-949.  doi: 10.3760/cma.j.issn.1673-422X.2014.12.020 Abstract ( 551 )   PDF (668KB) ( 1306 )   Save ObjectiveTo detect the expression of insulinlike growth factor Ⅱ mRNAbinding protein 3 (IMP3) and p16 in cervical carcinoma and investigate their clinical significance. MethodsImmunohistochemical Envision method was used to detect the expression of IMP3 and p16 proteins in 67 cases of carcinoma of the uterine cervix, 58 cases of cervical intraepithelial neoplasia (CIN) and 15 cases of normal cervical epithelium. ResultsIMP3 was mainly dedected  in the cytoplasm, whose positive expression rate was 85.07%（57/67）in cervical carcinoma, 12.07% (7/58) in CIN (χ2=66.32, P＜0.05) and 0 (0/15) in cervical epithelium (χ2=44.38, P＜0.05). No significance variations of the expression of IMP3 were observed in cervical adenocarcinoma and squamous cell carcinoma (χ2=0.35, P＞0.05). p16 was found both in nucleus and cytoplasm of cervical carcinoma, whose expression rate was 83.58% (56/67), higher than 41.37% (24/58) in CIN (χ2=24.85, P＜0.05) and 0 (0/15) in cervical epithelium (χ2=42.61, P＜0.05). ConclusionExpression of IMP3 and p16 is high in cervical carcinoma, maybe can be used as a potential biomarker of metastasis and progression. References | Related Articles | Metrics