Abstract: G-protein signaling 5 ( RGS5) belongs to RGS family, which can negatively regulate the conduction of this signaling pathway. RGS5 mainly expresses in vascular pericyte, and is closely related to the occurrence, development and maturation of the blood vessels. Loss of RGS5 results in pericyte maturation, tumor vascular normalization, and these changes can improve the curative effect of  combined chemotherapy and immunotherapy, indicating that RGS5 may become a new target of anti-tumor treatment. In addition, RGS5 involves in tumor metastasis and apoptosis, which can improve antineoplastic effect by inducing tumor cells apoptosis.

Key words: Neoplasms, Regulator of G-protein signaling 5