Abstract: MiR-494 involves in cell cycle regulation, differentiation and apoptosis processes of normal cells. Recent study shows that abnormal expression of miR-494 is associated with oncogenesis closely, and it participates in the invasion and metastasis of tumor cells and so on. MiR-494 is not only a tumor suppressor gene, but also can be considered as a cancer-promoting gene. MiR-494 can regulate the oncogenesis and development of the tumor through a variety of target genes and signaling pathways.

Key words: MicroRNAs, Neoplasms, Target gene