Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (8): 587-590.

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Regulation role of resveratrol in microRNAs expression in cancers

JI  Jia-Wen, ZHOU  Huai-Jun   

  1. Department of  Gynecology and Obstetrics, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 21008, China

  • Online:2013-08-08 Published:2013-08-15
  • Contact: Corresponding author: ZHOU Huai-jun,E-mail: zhouhj2007@126.com E-mail:zhouhj2007@126.com

Abstract: As a kind of polyphenolic phytoalexin, resveratrol exerts protective roles in anti-tumor, anti-inflammatory and promoting metabolism. Resveratrol’s anti-tumor mechanisms may be involved in upregulating tumor suppressor microRNAs and downregulating oncogenic microRNAs, and affect its relative pathways and target genes in different cancers such as colon cancers and breast cancers. This will provide a new theoretical basis for the further clarification of resveratrol-associated tumor suppressing mechanisms and its application to the clinical.

Key words: MicroRNAs, Neoplasms, Resveratrol