Abstract: Ecotropic viral integration site-1 (Evi-1) gene is first identified as a binding site for retrovirus in murine myeloid leukemia. The human homologue with the murine in leukemia oncogene Evi-1 is about 91% of nuclear sequence and 94% of amino acid. Evi-1 gene is high expressed in myeloid malignancies and other tumors. The main tumorigenic mechanisms of Evi-1 gene include inhibiting TGF-β signal path by depressing Smad3, adjusting cell cycle, promoting angiogenesis, inhibiting JNK, activating AP-1, and so on.

Key words:  Evi-1 gene, Smad3 protein, Leukemia, TGF-&beta, signal transduction, Neoplasms