Research progress of myeloid-derived suppressor cells in tumor angiogenesis

doi:10.3760/cma.j.cn371439-20230227-00006

Abstract

Abstract:

As a kind of immunosuppressive cells， myeloid-derived suppressor cells （MDSCs） are an important component of the immune microenvironment. MDSCs play a significant role in promoting tumor immune escape. In addition， non-immunological functions such as promoting angiogenesis can also promote tumor development with the deepening of research. MDSCs can promote tumor angiogenesis directly through vascular endothelial growth factor signaling pathway， or promote tumor growth and angiogenesis by secreting cytokines such as matrix metalloprotein-9， basic fibroblast growth factor， angiogenic peptide Bv8， platelet derived growth factor， exosomes， or interacting with other cells. Exploring the expansion， activation， recruitment and angiogenesis mechanism of MDSCs will provide new ideas for regulating the individualized diagnosis and treatment based on targeted MDSCs.

Key words: Myeloid-derived suppressor cells, Tumor microenvironment, Angiogenesis

Liu Xiaodi, Su Jianfei, Zhang Jingxian, Wei Xueqin, Jia Yingjie. Research progress of myeloid-derived suppressor cells in tumor angiogenesis[J]. Journal of International Oncology, 2024, 51(1): 50-54.

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