Role of cancer-associated fibroblasts in breast cancer

doi:10.3760/cma.j.cn371439-20201208-00120

Abstract

Abstract:

The interaction between breast cancer cells and the tumor microenvironment plays a vital role in the occurrence and development of breast cancer. Cancer-associated fibroblasts are heterogeneous stromal cells that are abundant in the tumor microenvironment. They participate in tumor angiogenesis, treatment resistance and distant metastasis by secreting a variety of cytokines, growth factors and chemokines. It has great potential as a biomarker for targeted therapy and clinical prognosis of breast cancer, and it can also provide new ideas for adjuvant treatment of breast cancer.

Key words: Breast neoplasms, Cancer-associated fibroblasts, Tumor microenvironment

Wang Ailing, Niu Ximei, Huang Guofu, Leng Xiaoling. Role of cancer-associated fibroblasts in breast cancer[J]. Journal of International Oncology, 2021, 48(10): 614-617.

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