Journal of International Oncology ›› 2021, Vol. 48 ›› Issue (3): 164-166.doi: 10.3760/cma.j.cn371439-20200401-00032

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Thrombospondin 2 and tumors

Fan Chongchong, Qiao Jian'ou*()   

  1. Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
  • Received:2020-04-01 Revised:2020-11-15 Online:2021-03-08 Published:2021-03-25
  • Contact: Qiao Jian'ou E-mail:qjou@163.com
  • Supported by:
    National Natural Science Foundation of China(81170028)

Abstract:

Thrombospondin (THBS) 2, as a member of the THBS family, is expressed in a variety of tumor cells and has important significance in the development and metastasis of tumors. In recent years, studies have reported that the specific role of THBS2 in different tumors is different, and it participates in a variety of biological processes, such as cell apoptosis, wound healing, angiogenesis and inflammation. At present, the role of THBS2 in tumorigenesis, development, and prognosis is not completely clear. Exploring the abnormal expression and mechanism of THBS2 in tumors is expected to provide a new method for tumor diagnosis and treatment.

Key words: Neoplasms, Thrombospondin 2