Mechanisms of ferroptosis and its significance in breast cancer therapy

doi:10.3760/cma.j.cn371439-20191206-00039

Abstract

Abstract:

Breast cancer is a malignant tumor originating from breast epithelial tissue. Ferroptosis is a novel type of programmed cell death which differs from apoptosis and necrosis. Research found that the accumulation of lipid peroxides in cells, a crucial process of ferroptosis, can be induced by multiple mechanisms. The ferroptosis regulation is closely related to the occurrence and development of breast cancer, and it induced by drugs is a potential and valuable research direction in breast cancer.

Key words: Breast neoplasms, Reactive oxygen species, Ferroptosis

Xu Yiyue, Zhao Shaorong, Liu Jingjing, Zhang Jin. Mechanisms of ferroptosis and its significance in breast cancer therapy[J]. Journal of International Oncology, 2020, 47(6): 372-376.

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