Journal of International Oncology ›› 2020, Vol. 47 ›› Issue (6): 372-376.doi: 10.3760/cma.j.cn371439-20191206-00039

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Mechanisms of ferroptosis and its significance in breast cancer therapy

Xu Yiyue, Zhao Shaorong, Liu Jingjing, Zhang Jin()   

  1. Third Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Clinical Research Center for Cancer of Tianjin, Tianjin 300060, China
  • Received:2019-12-06 Revised:2019-12-19 Online:2020-06-08 Published:2020-07-22
  • Contact: Zhang Jin E-mail:zhangjintjmuch1@163.com
  • Supported by:
    National Natural Science Foundation of China(81672623)

Abstract:

Breast cancer is a malignant tumor originating from breast epithelial tissue. Ferroptosis is a novel type of programmed cell death which differs from apoptosis and necrosis. Research found that the accumulation of lipid peroxides in cells, a crucial process of ferroptosis, can be induced by multiple mechanisms. The ferroptosis regulation is closely related to the occurrence and development of breast cancer, and it induced by drugs is a potential and valuable research direction in breast cancer.

Key words: Breast neoplasms, Reactive oxygen species, Ferroptosis