Research progress on the mechanism of β human papillomavirus induced cutaneous squamous cell carcinoma

doi:10.3760/cma.j.issn.1673-422X.2019.12.011

Abstract

Abstract: Human papillomaviruse （HPV） infects squamous epithelium and induces hyperproliferative lesions. β human papillomavirus (β-HPV) is a common type of HPV according to the nucleic acid sequence of L1 protein. In recent years, the incidence of cutaneous squamous cell carcinoma (CSCC) has increased, βHPV may be involved in the pathogenesis of CSCC. Besides, β-HPV inhibits p53 and pRb tumor suppressor genes through virus E6 and E7 proteins, which plays an important role in the initial stage of cancer. Therefore, the β-HPV is a target for preventing CSCC, especially for patients with immunosuppression who have received organ transplantation.

Key words: Neoplasms, squamous cell, Betapapillomavirus, Mechanism

Ma Qingyu, Liang Junqin. Research progress on the mechanism of β human papillomavirus induced cutaneous squamous cell carcinoma[J]. Journal of International Oncology, 2019, 46(12): 760-763.

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