Journal of International Oncology ›› 2019, Vol. 46 ›› Issue (10): 601-604.doi: 10.3760/cma.j.issn.1673-422X.2019.10.006

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Expression of miR-490 in malignant tumors and its molecular mechanism

Deng Siyuan1,2, He De2   

  1. 1Postgraduate College of Guangdong Medical University, Zhanjiang 524023, China; 2Shenzhen Baoan Clinical Medical College of Guangdong Medical University, Shenzhen 518101, China

  • Online:2019-10-08 Published:2019-12-20
  • Contact: He De, Email: hede1965@126.com E-mail:hede1965@126.com

Abstract:

微小RNA-490 (miR-490)miRNA家族中重要的一员,其与肿瘤的发生、发展密切相关。研究表明miR490在胃癌、结直肠癌、乳腺癌等多种肿瘤中异常表达,并在不同肿瘤细胞的增殖、凋亡、侵袭、转移等生物学行为中扮演着癌基因或抑癌基因的角色。miR-490有望作为肿瘤诊断和临床预后的指标,对其机制的深入研究有望为肿瘤诊治提供新的方向。

Key words: MicroRNAs, Neoplams, Gene expression, Mechanism, miR-490