Extracellular vesicles in promoting the invasion and metastasis of pancreatic cancer

doi:10.3760/cma.j.issn.1673422X.2016.12.017

Abstract

Abstract: The secretion of extracellular vesicles (EVs) is a wellconserved evolutionary process that occurs from prokaryotic cells to eukaryotes. EVs have been identified in body fluids such as plasma, urine, ascites, and bile as well as tumor microenvironment. EVs play an important role in cell growth, movement, signal transduction, invasion and metastasis of tumor cells. With a high invasive ability, pancreatic cancer has a high degree of malignancy. Evs can enhance the invasion and metastasis of pancreatic cancer by increasing cell proliferation, inhibiting immune responses, promoting angiogenesis and extracellular matrix remodeling.

Key words: Pancreatic neoplasms, Neoplasm invasiveness, Neoplasm metastasis, Extracellular vesicles

LIU Bao-Rui, WU Yong-Na, ZHOU Wen-Ce. Extracellular vesicles in promoting the invasion and metastasis of pancreatic cancer[J]. Journal of International Oncology, 2016, 43(12): 947-949.

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