Long noncoding RNA in leukemia

doi:10.3760/cma.j.issn.1673422X.2016.12.018

Abstract

Abstract: Recent studies show that some long noncoding RNA (lncRNA) is specifically expressed in leukemia with mixed lineage leukemia (MLL)rearranged, BCRABL, promyelocytic leukemiaretinoic acid receptor α (PMLRARα), and acute myeloid leukemia 1 (AML1)ETO fusion gene, which is closely related to the occurrence, development and prognosis of leukemia. Specifically expressed lncRNA may provide new strategies for the diagnosis and treatment, which may provide a guidance for clinical prognosis of leukemia.

Key words: Leukemia, Karyotype, Long noncoding RNA

HU Lin-Hui, XIONG Shu-Dao. Long noncoding RNA in leukemia[J]. Journal of International Oncology, 2016, 43(12): 950-952.

References

［1］ Iyer MK, Niknafs YS, Malik R, et al. The landscape of long noncoding RNAs in the human transcriptome［J］. Nat Genet, 2015, 47(3): 199208. DOI: 10.1038/ng.3192. ［2］ Rinn JL, Kertesz M, Wang JK, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs［J］. Cell, 2007, 129(7): 13111323. ［3］ Carrieri C, Cimatti L, Biagioli M, et al. Long noncoding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat［J］. Nature, 2012, 491(7424): 454457. DOI: 10.1038/nature11508. ［4］ Yoon JH, Abdelmohsen K, Srikantan S, et al. LincRNAp21 suppresses target mRNA translation［J］. Mol Cell, 2012, 47(4): 648655. DOI: 10.1016/j.molcel.2012.06.027. ［5］ Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition［J］. Nature, 2014, 505(7483): 344352. DOI: 10.1038/nature12986. ［6］ RodriguezMalavé NI, Rao DS. Long noncoding RNAs in hematopoietic malignancies［J］. Brief Funct Genomics, 2015, In press. ［7］ Fang K, Han BW, Chen ZH, et al. A distinct set of long noncoding RNAs in childhood MLLrearranged acute lymphoblastic leukemia: biology and epigenetic target［J］. Hum Mol Genet, 2014, 23(12): 32783288. DOI: 10.1093/hmg/ddu040. ［8］ Fernando TR, RodriguezMalave NI, Waters EV, et al. LncRNA expression discriminates karyotype and predicts survival in Blymphoblastic leukemia［J］. Mol Cancer Res, 2015, 13(5): 839851. DOI: 10.1158/15417786.MCR150006T. ［9］ RodriguezMalavé NI, Fernando TR, Patel PC, et al. BALR6 regulates cell growth and cell survival in Blymphoblastic leukemia［J］. Mol Cancer, 2015, 14: 214. DOI: 10.1186/s129430150485z. ［10］ Guo G, Kang Q, Zhu X, et al. A long noncoding RNA critically regulates BcrAblmediated cellular transformation by acting as a competitive endogenous RNA［J］. Oncogene, 2015, 34(14): 17681779. DOI: 10.1038/onc.2014.131. ［11］ Guo G, Kang Q, Chen Q, et al. High expression of long noncoding RNA H19 is required for efficient tumorigenesis induced by BcrAbl oncogene［J］. FEBS Lett, 2014, 588(9): 17801786. DOI: 10.1016/j.febslet. 2014.03.038. ［12］ Le Beau MM, Bitts S, Davis EM, et al. Recurring chromosomal abnormalities in leukemia in PMLRARA transgenic mice parallel human acute promyelocytic leukemia［J］. Blood, 2002, 99(8): 29852991. ［13］ Zeng C, Yu X, Lai J, et al. Overexpression of the long noncoding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia［J］. J Hematol Oncol, 2015, 8(1): 126. DOI: 10.1186/s1304501502234. ［14］ Chinen Y, Sakamoto N, Nagoshi H, et al. 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia［J］. J Hematol Oncol, 2014, 7: 68. DOI: 10.1186/s1304501400682. ［15］ Zeng C, Xu Y, Xu L, et al. Inhibition of long noncoding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells［J］. BMC Cancer, 2014, 14: 693. DOI: 10.1186/1471240714693. ［16］ Wang H, Li W, Guo R, et al. An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies［J］. Int J Cancer, 2014, 135(12): 27832794. DOI: 10.1002/ijc.28922. ［17］ Garzon R, Volinia S, Papaioannou D, et al. Expression and prognostic impact of lncRNAs in acute myeloid leukemia［J］. Proc Natl Acad Sci USA, 2014, 111(52): 1867918684. DOI: 10.1073/pnas.1422050112.

[1]	Teng Yuan, Li Lijuan, Zhang Liansheng. Progress of MCL-1 and its inhibitors in hematologic malignancies [J]. Journal of International Oncology, 2024, 51(2): 119-122.
[2]	Wang Jun, Jia Xiuhong. TGF-β/Smad signal pathway and acute leukemia [J]. Journal of International Oncology, 2023, 50(8): 498-502.
[3]	Wang Ting, Li Wenqian, Xie Youbang. Correlation between hypoxia and the oxygen sensing pathway in acute myeloid leukemia cells [J]. Journal of International Oncology, 2023, 50(8): 503-507.
[4]	Zhang Ting, Jia Xiuhong. Research progress of pyroptosis in leukemia [J]. Journal of International Oncology, 2023, 50(11): 696-700.
[5]	Lu Jialing, Huang Huijuan, Liu Dan, Chen Yanxin, Ma Xiao, Wu Depei. Efficacy and safety of blinatumomab in the treatment of B-cell acute lymphoblastic leukemia [J]. Journal of International Oncology, 2022, 49(8): 494-498.
[6]	Zhou Xinyu, Jia Xiuhong. Research progress of ferroptosis in the treatment of leukemia [J]. Journal of International Oncology, 2022, 49(12): 759-762.
[7]	Chen Xi, Mu Dan, Yan Qin, Liu Wenjun. Bone marrow microenvironment and differentiation of leukemia cells [J]. Journal of International Oncology, 2021, 48(3): 189-192.
[8]	Li Weiqiang, Wu Yang, Wan Chonghua, Tan Jianfeng, He Zhengchun, Meng Qiong. Establishing minimal clinically important differences of Quality of Life Instruments for Cancer Patients-Leukemia based on the distribution-based approach [J]. Journal of International Oncology, 2021, 48(10): 577-582.
[9]	Xu Lei, Dai Jing, Zhang Qian, Zhang Wenli, Li Jinmeng, Zhang Hongyu. Clinical analysis of 93 cases of adult patients with acute lymphoblastic leukemia [J]. Journal of International Oncology, 2020, 47(9): 535-541.
[10]	Sun Wangnan, Du Pengchao, Qi Fu, Wang Wenfeng, Jiang Guosheng. Effect of miR-5581-5p/TRIM22 on acute promyelocytic leukemia cell differentiation [J]. Journal of International Oncology, 2020, 47(3): 129-134.
[11]	Hong Li, Wang Yu, Zhang Qi, Lyu Chengfang. Nilotinib in first-line treatment of chronic myeloid leukemia [J]. Journal of International Oncology, 2020, 47(1): 56-59.
[12]	Lei Lin, Ji Yong, Shang Qinggang, Peng Ji, Ren Hua. Epidemiologic features and trends of leukemia in Shenzhen during 2001-2015 [J]. Journal of International Oncology, 2019, 46(7): 415-419.
[13]	Si Sainyu, Wang Huaying, Yu Wanjun, Li Jipeng. Role of leukemia inhibitory factor in tumorigenesis and development [J]. Journal of International Oncology, 2019, 46(10): 605-608.
[14]	Zhang Yun, Ji Xiluan, Luo Zhaoxia, Yang Shun, Shang Yanhong, Xie Liang, Jia Youchao, Li Jieming, Zang Aimin, Jiang Shu. Experimental study on bi-chimeric antigen receptors modified T- lymphocytes targeting on acute myeloid leukemia [J]. Journal of International Oncology, 2018, 45(7): 385-390.
[15]	Li Congchi*, Hou Lihong. Prognostic significance of peripheral blood absolute lymphocyte count in acute lymphoblastic leukemia [J]. Journal of International Oncology, 2018, 45(1): 49-.