Mechanism of FOXA2 in colorectal cancer and its application in diagnosis and treatment

doi:10.3760/cma.j.cn371439-20220429-00094

Abstract

Abstract:

Forkhead box protein A2 （FOXA2）, characterized by its unique DNA binding domain, plays a key role in transcriptional regulation. FOXA2 transcription factor is highly expressed in colorectal cancer, and binds with corresponding targeted genes to regulate tumor growth and inflammatory response, thus playing the role of oncogenes. In-depth understanding of the role and function of human FOXA2 transcription factor in colorectal cancer will contribute to further development of FOXA2 as a potential therapeutic target and diagnostic and prognostic marker of colorectal cancer.

Key words: Colorectal neoplasms, Forkhead box protein, FOXA2

Huang Mengpan, Wang Xuehong, Lu Yongfu. Mechanism of FOXA2 in colorectal cancer and its application in diagnosis and treatment[J]. Journal of International Oncology, 2022, 49(8): 490-493.

References 25

[1]	Li C, Liu T, Liu Y, et al. Prognostic value of tumour microen-vironment-related genes by TCGA database in rectal cancer[J]. J Cell Mol Med, 2021, 25(12): 5811-5822. DOI: 10.1111/jcmm.16547. doi: 10.1111/jcmm.16547
[2]	Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. DOI: 10.3322/caac.21660. doi: 10.3322/caac.21660
[3]	Zhang N, Ng AS, Cai S, et al. Novel therapeutic strategies: targe-ting epithelial-mesenchymal transition in colorectal cancer[J]. Lancet Oncol, 2021, 22(8): e358-e368. DOI: 10.1016/S1470-2045(21)00343-0. doi: 10.1016/S1470-2045(21)00343-0 pmid: 34339656
[4]	Erfani M, Zamani M, Hosseini SY, et al. ARID1A regulates E-cadherin expression in colorectal cancer cells: a promising candidate therapeutic target[J]. Mol Biol Rep, 2021, 48(10): 6749-6756. DOI: 10.1007/s11033-021-06671-9. doi: 10.1007/s11033-021-06671-9
[5]	Bow YD, Wang YY, Chen YK, et al. Silencing of FOXA2 decreases E-cadherin expression and is associated with lymph node metastasis in oral cancer[J]. Oral Dis, 2020, 26(4): 756-765. DOI: 10.1111/odi.13282. doi: 10.1111/odi.13282
[6]	Wang B, Liu G, Ding L, et al. FOXA2 promotes the proliferation, migration and invasion, and epithelial mesenchymal transition in colon cancer[J]. Exp Ther Med, 2018, 16(1): 133-140. DOI: 10.3892/etm.2018.6157. doi: 10.3892/etm.2018.6157
[7]	Huang Y, Shen XJ, Zou Q, et al. Biological functions of micro-RNAs: a review[J]. J Physiol Biochem, 2011, 67(1): 129-139. DOI: 10.1007/s13105-010-0050-6. doi: 10.1007/s13105-010-0050-6 pmid: 20981514
[8]	Iorio MV, Croce CM. MicroRNA involvement in human cancer[J]. Carcinogenesis, 2012, 33(6): 1126-1133. DOI: 10.1093/carcin/bgs140. doi: 10.1093/carcin/bgs140
[9]	Sun C, Li S, Yang C, et al. MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6[J]. Biochem Biophys Res Commun, 2016, 471(1): 82-88. DOI: 10.1016/j.bbrc.2016.01.175. doi: 10.1016/j.bbrc.2016.01.175
[10]	Casanova-Salas I, Masiá E, Armiñán A, et al. MiR-187 targets the androgen-regulated gene ALDH1A3 in prostate cancer[J]. PLoS One, 2015, 10(5): e0125576. DOI: 10.1371/journal.pone.0125576. doi: 10.1371/journal.pone.0125576
[11]	Mulrane L, Madden SF, Brennan DJ, et al. MiR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro[J]. Clin Cancer Res, 2012, 18(24): 6702-6713. DOI: 10.1158/1078-0432.CCR-12-1420. doi: 10.1158/1078-0432.CCR-12-1420
[12]	Zhang F, Luo Y, Shao Z, et al. MicroRNA-187, a downstream effector of TGFβ pathway, suppresses Smad-mediated epithelial-mesenchymal transition in colorectal cancer[J]. Cancer Lett, 2016, 373(2): 203-213. DOI: 10.1016/j.canlet.2016.01.037. doi: 10.1016/j.canlet.2016.01.037
[13]	Li C, Lu S, Shi Y. MicroRNA-187 promotes growth and metastasis of gastric cancer by inhibiting FOXA2[J]. Oncol Rep, 2017, 37(3): 1747-1755. DOI: 10.3892/or.2017.5370. doi: 10.3892/or.2017.5370
[14]	Wang J, Li B, Zhao K, et al. 2-Amino-4-(1-piperidine) pyridine exhibits inhibitory effect on colon cancer through suppression of FOXA2 expression[J]. 3 Biotech, 2019, 9(11): 384. DOI: 10.1007/s13205-019-1915-1. doi: 10.1007/s13205-019-1915-1
[15]	Lee H, Jeong AJ, Ye SK. Highlighted STAT3 as a potential drug target for cancer therapy[J]. BMB Rep, 2019, 52(7): 415-423. DOI: 10.5483/BMBRep.2019.52.7.152. doi: 10.5483/BMBRep.2019.52.7.152
[16]	Zou S, Tong Q, Liu B, et al. Targeting STAT3 in cancer immunotherapy[J]. Mol Cancer, 2020, 19(1): 145. DOI: 10.1186/s12943-020-01258-7. doi: 10.1186/s12943-020-01258-7
[17]	Wang J, Lu H, Wang W, et al. Hepatocyte nuclear factor 3β plays a suppressive role in colorectal cancer progression[J]. Front Oncol, 2019, 9: 1096. DOI: 10.3389/fonc.2019.01096. doi: 10.3389/fonc.2019.01096
[18]	Chen R, Wang L, Zhao Q, et al. Platelet-to-lymphocyte ratio and C-reactive protein as markers for colorectal polyp histological type[J]. BMC Cancer, 2021, 21(1): 556. DOI: 10.1186/s12885-021-08221-9. doi: 10.1186/s12885-021-08221-9 pmid: 34001040
[19]	Boregowda U, Desai M, Nutalapati V, et al. Impact of feedback on adenoma detection rate: a systematic review and meta-analysis[J]. Ann Gastroenterol, 2021, 34(2): 214-223. DOI: 10.20524/aog.2021.0591. doi: 10.20524/aog.2021.0591
[20]	朱晓佳, 杨力. 结肠镜腺瘤检出率的近期研究进展[J]. 世界华人消化杂志, 2021, 29(22): 1304-1310. DOI: 10.11569/wcjd.v28.i22.1304. doi: 10.11569/wcjd.v28.i22.1304
[21]	鞠乐乐, 颜玉, 陈曦, 等. 内镜下结直肠息肉临床特点及病理分析[J]. 黑龙江医药科学, 2019, 42(6): 14-15. DOI: 10.3969/j.issn.1008-0104.2019.06.005. doi: 10.3969/j.issn.1008-0104.2019.06.005
[22]	彭好, 沈磊. Foxa2在结直肠息肉和结直肠癌中的表达及其意义[J]. 胃肠病学, 2019, 24(11): 655-659. DOI: 10.3969/j.issn.1008-7125.2019.11.004. doi: 10.3969/j.issn.1008-7125.2019.11.004
[23]	Lehner F, Kulik U, Klempnauer J, et al. The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases[J]. FASEB J, 2007, 21(7): 1445-1462. DOI: 10.1096/fj.06-6575com. doi: 10.1096/fj.06-6575com pmid: 17283222
[24]	Zhan X, Zhao A. Transcription factor FOXA3 promotes the deve-lopment of hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression[J]. J Clin Lab Anal, 2021, 35(3): e23686. DOI: 10.1002/jcla.23686. doi: 10.1002/jcla.23686
[25]	Teng S, Li YE, Yang M, et al. Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer[J]. Cell Res, 2020, 30(1): 34-49. DOI: 10.1038/s41422-019-0259-z. doi: 10.1038/s41422-019-0259-z