N6-methyladenine methylation regulators and cancer

doi:10.3760/cma.j.cn371439-20200615-00018

Abstract

Abstract:

N⁶-methyladenine (m⁶A) is the most abundant internal RNA modification found in a variety of eukaryotic messenger RNAs and long non-coding RNAs, which is dynamically regulated by m⁶A methyltransferases and demethylases, and mainly works after recognized by m⁶A binding proteins. m⁶A is involved in almost every step of the RNA life cycle, including RNA transcription, splicing, localization, nuclear transport, translation, and degradation. Disorder of m⁶A modification can lead to RNA dysfunction and abnormal gene expression. m⁶A modification regulators express abnormally in various cancers, and play an important role in cancer formation, proliferation, differentiation, invasion and metastasis.

Key words: Neoplasms, RNA, messenger, Methylation

Zeng Juan, Yang Xianghong. N⁶-methyladenine methylation regulators and cancer[J]. Journal of International Oncology, 2021, 48(2): 96-100.

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N⁶-methyladenine methylation regulators and cancer

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