Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (5): 393-396.doi: 10.3760/cma.j.issn.1673422X.2017.05.018

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Efficacy of VEGF and VEGFR pathway inhibitors in the treatment of advanced gastric cancer

Li Maoji, Jiang Lei, Guan Quanlin   

  1. Department of Medical Oncology, First Hospital of Lanzhou University, Lanzhou 730000, China
  • Online:2017-05-08 Published:2017-04-19
  • Contact: Guan Quanlin E-mail:guanquanlin@163.com
  • Supported by:

    Science and Technology Support Project of Gansu Province of China(1504FKCA084); Health Industry Science Foundation of Gansu Province of China(GSWST2013-16)

Abstract: |Antineovascularization is an important research direction in the current treatment of gastric cancer. The inhibitors of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) are main research focus. At present, the inhibitors of the pathways of VEGF and VEGFR in the treatment of advanced gastric cancer include bevacizumab, ramucirumab, apatinib, regorafenib, sorafenib, et al. These drugs provide more possibilities for the treatment of advanced gastric cancer.

Key words: Vascular endothelial growth factors, Receptors, vascular endothelial growth factor, Stomach neoplasms