Journal of International Oncology

Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (10): 723-726.

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Roles of Pim-1 in tumors and related signaling pathways

LIANG  Zhi-Jie, JIA  Miao-Miao, ZHANG  Bin, et al   

  1. First Department of Breast Surgery, Affiliated Cancer Hospital of Tianjin Medical University; Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education; Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: Cao Xu-chen, E-mail: cxc@medmail.com.cn E-mail:cxc@medmail.com.cn

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Abstract: The overexpression of proto-oncogene proteins c-pim-1 (Pim-1) in tumor tissue is related to the stage and prognosis. Recent studies indicate that Pim-1 plays a critical role in the proliferation and apoptosis of cells and the metastasis of tumor. Pim-1 acts as an essential factor in several signaling pathways and its expression and activation are regulated by many factors as well as affects others widely. As an influential factor in the occurrence and development of tumor, Pim-1 has been a potential target in oncotherapy.

Key words: Proto-oncogene proteins c-pim-1, Neoplasms, Protein-serine-threonine kinases, Signal transduction