Epithelial-mesenchymal transition and gastric cancer

doi:10.3760/cma.j.issn.1673-422X.2013.12.014

Abstract

Abstract: Epithelialmesenchymal transition (EMT) is that cells undergo a switch from epithelial phenotype to mesenchymal phenotype. Recent researches show that EMT can affect the occurrence and development of gastric cancer through a variety of mechanisms and promote the migration and invasion of tumor cells. The process of EMT involves a number of signal transduction pathways, and is related to microRNAs, Helicobacter pylori, transcription factors and so on. EMT is expected to be a novel therapeutic target of gastric cancer.

Key words: Stomach neoplasms, Signal transduction, Neoplasm metastasis, Epithelial-mesenchymal transition

LIU Li-Min, LI Ji-Kun. Epithelial-mesenchymal transition and gastric cancer[J]. Journal of International Oncology, 2013, 40(12): 924-926.

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