EMT mediated cancer stemness and tumor

doi:10.3760/cma.j.issn.1673-422X.2013.12.006

Abstract

Abstract: Epithelialmesenchymal transition (EMT) is a major mechanism in tumor metastasis. As the key regulatory factor, Twist gene plays an important role in EMT, and it can be induced by radiotherapy, chemotherapy and a variety of cytokines. Researches show that tumor cells can get stem celllike properties via EMT, which can lead to chemoradiotherapy resistance, tumor angiogenesis and distant metastasis. EMT has a great influence on the prognosis of tumor, and it is expected to become an important target for tumor treatment.

Key words: Cell transformation, neoplastic, Neoplastic stem cells, Twist transcription factor

DENG Chun-Yan, TAN Xiao-Qin, LI Tao, HUANG Jian-Ming. EMT mediated cancer stemness and tumor[J]. Journal of International Oncology, 2013, 40(12): 899-902.

References

［1］ Chen C, Zimmermann M, Tinhofer I, et al. Epithelialtomesenchymal transition and cancer stem(like) cells in head and neck squamous cell carcinoma. Cancer Lett, 2013, 338(1): 4756. ［2］ Wu KJ. Direct activation of Bmi1 by Twist1: implications in cancer stemness, epithelialmesenchymal transition, and clinical significance. Chang Gung Med J, 2011, 34(3): 229238. ［3］ SanchezTillo E, Liu Y, de Barrios O, et al. EMTactivating transcription factors in cancer: beyond EMT and tumor invasiveness.Cell Mol Life Sci, 2012, 69(20): 34293456. ［4］ Zhang X, Li X, Zhang N, et al. Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelialmesenchymal transition. Biochem Biophys Res Commun, 2011, 412(1): 188192. ［5］ Kawamoto A, Yokoe T, Tanaka K, et al. Radiation induces epithelialmesenchymal transition in colorectal cancer cells. Oncol Rep, 2012, 27(1): 5157. ［6］ Li QQ, Chen ZQ, Cao XX, et al. Involvement of NFκb/miR448 regulatory feedback loop in chemotherapyinduced epithelialmesenchymal transition of breast cancer cells. Cell Death Differ, 2011, 18(1): 1625. ［7］ Lalifi A, Abubaker K, Castrechini N, et al. Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem celllike profile. J Cell Biochem, 2011, 112(10): 28502864. ［8］ Lo HW, Hsu SC, Xia WY, et al. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelialmesenchymal transition in cancer cells via upregulation of Twist gene expression. Cancer Res, 2007, 67(19): 90669076. ［9］ Cheng JC, Auersperg N, Leung PC. TGFbeta induces serous borderline ovarian tumor cell invasion by activating EMT but triggers apoptosis in lowgrade serous ovarian carcinoma cells. PLoS One, 2012, 7(8): e42436. ［10］ Xie G, Yao Q, Liu Y, et al. IL6induced epithelialmesenchymal transition promotes the generation of breast cancer stemlike cells analogous to mammosphere cultures. Int J Oncol, 2012, 40(4): 11711179. ［11］ Sun S, Ning X, Zhang Y, et al. Hypoxiainducible factor1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelialtomesenchymal transition. Kidney Int, 2009, 75(12): 12781287. ［12］ Shimojo Y, Akimoto M, Hisanaga T, et al. Attenuation of reactive oxygen species by antioxidants suppresses hypoxiainduced epithelialmesenchymal transition and metastasis of pancreatic cancer cells. Clin Exp Metastasis, 2013, 30(2): 143154. ［13］ Battula VL, Evans KW, Hollier BG, et al. Epithelialmesenchymal transitionderived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells. Stem Cells, 2010, 28(8): 14351445. ［14］ Du Z, Qin R, Wei C, et al. Pancreatic cancer cells resistant to chemoradiotherapy rich in "Stemcelllike" tumor cells. Dig Dis Sci, 2011, 56(3): 741750. ［15］ Li J, Zhou BP. Activation of βcatenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem celllike characters. BMC Cancer, 2011, 11: 49. ［16］ Chen C, Wei Y, Hummel M, et al. Evidence for epithelialmesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma. PLoS One, 2011, 6(1): e16466. ［17］ Vanqipuram SD, Wang ZJ, Lyman WD. Resistance of stemlike cells from neuroblastoma cell lines to commonly used chemotherapeutic agents. Pediatr Blood Cancer, 2010, 54(3): 361368. ［18］ Wu CY, Hung JJ, Wu KJ, et al. Linkage between Twist1 and Bmi1: molecular mechanism of cancer metastasis/stemness and clinical implications. Clin Exp Pharmacol Physiol, 2012, 39(8): 668673. ［19］ Krause M, Yaromina A, Eicheler W, et al. Cancer stem cells: targets and potential biomarkers for radiotherapy. Clin Cancer Res, 2011, 17(23): 72247229. ［20］ Oqawa K, Yoshioka Y, Isohashi F, et al. Radiotherapy targeting cancer stem cells: current views and future perspectives. Anticancer Res, 2013, 33(3): 747754. ［21］ Rich JN. Cancer stem cells in radiation resistance. Cancer Res, 2007, 67(19): 89808984. ［22］ Folkins C, Shaked Y, Man S, et al. Glioma tumor stemlike cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromalderived factor 1. Cancer Res, 2009, 69(18): 72437251. ［23］ RicciVitiani L, Pallini R, Todara M, et al. Tumour vascularization via endothelial differentiation of glioblastoma stemlike cells. Nature, 2010, 468(7325): 824828. ［24］ Yang L, Ping YF, Yu X, et al. Gastric cancer stemlike cells possess higher capability of invasion and metastasis in association with a mesenchymal transition phenotype. Cancer Lett, 2011, 310(1): 4652. ［25］ Zhang Y, Wang Z, Yu J, et al. Cancer stemlike cells contribute to cisplatin resistance and progression in bladder cancer. Cancer Lett, 2012, 322(1): 7077.

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