Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (12): 902-904.doi: 0.3760/cma.j.issn.1673-422X.2013.12.007

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Roles of SIRT1 in tumorigenesis and tumor progression

FU  De-Qiang, WU  Wen-Yi, ZHANG  Li-Ting   

  1. Second Clinical Medical College of Fujian Medical University, Quanzhou 362000, China
  • Online:2013-12-10 Published:2013-12-26
  • Contact: WU Wen-Yi, E-mail:wwyii8522858@163.com

Abstract: Silent information regulator 1 (SIRT1) is a kind of histone deacetylase which dependents on nicotinamide adenine dinucleotide. It is involved in the occurrence and development of tumors. Data show that SIRT1 is highly expressed in many tumors, such as gastric cancer, breast cancer, prostate cancer and so on. On the other hand, the expression of SIRT1 is lower in many other types of tumors, including glioblastomas, bladder cancer, ovarian cancer and so on. Therefore, the role of SIRT1 in tumor formation process is still uncertain and controversial.

Key words: Neoplasms, Silent information regulator 1