Abstract: Notch signaling pathway is involved in the abnormal differentiation and selfrenewal of lung cancer stem cells. The further studies for the roles of Notch signaling pathway in the regulation of lung cancer stem cells are expected to find new targets in the diagnosis and treatment of lung cancer. Inhibitors of the Notch signaling pathway may be effective in the treatment of lung cancer. Lung cancer stem cells are thought to be a major cause of recurrence of lung cancer, therefore, targeted therapy for lung cancer stem cells may be more effective than treatment for the entire tumor.

Key words: Receptors, Notch, Lung neoplasms, Neoplastic stem cells, Inhibitors