Role of tumor cell-derived exosomes in the pre-metastatic niche formation in colorectal cancer

doi:10.3760/cma.j.cn371439-20240429-00109

Abstract

Abstract:

Distant metastasis is the main cause of death in patients with advanced colorectal cancer， and tumor cell-derived exosomes， as mediators of information transfer， are widely involved in all aspects of pre-metastatic niche formation in colorectal cancer. In-depth study of the mechanism of exosomes in the formation of pre-metastatic niche can provide new ideas for targeted therapy and prediction of tumor progression in colorectal cancer.

Key words: Exosomes, Tumor microenvironment, Colorectal neoplasms, Neoplasm metastasis, Pre-metastatic niche

Chen Jie, Xu Hong, Chen Yutian. Role of tumor cell-derived exosomes in the pre-metastatic niche formation in colorectal cancer[J]. Journal of International Oncology, 2024, 51(10): 650-654.

References 36

[1]	郑荣寿, 陈茹, 韩冰峰, 等. 2022年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志, 2024, 46(3): 221-231. DOI: 10.3760/cma.j.cn112152-20240119-00035.
[2]	Herath S, Razavi Bazaz S, Monkman J, et al. Circulating tumor cell clusters: insights into tumour dissemination and metastasis[J]. Expert Rev Mol Diagn, 2020, 20(11): 1139-1147. DOI: 10.1080/14737159.2020.1846523. pmid: 33140979
[3]	Doglioni G, Parik S, Fendt SM. Interactions in the (Pre)metastatic niche support metastasis formation[J]. Front Oncol, 2019, 9: 219. DOI: 10.3389/fonc.2019.00219. pmid: 31069166
[4]	Titu S, Gata VA, Decea RM, et al. Exosomes in colorectal cancer: from physiology to clinical applications[J]. Int J Mol Sci, 2023, 24(5): 4382. DOI: 10.3390/ijms24054382.
[5]	Liu C, Xia C, Xia C. Biology and function of exosomes in tumor immunotherapy[J]. Biomed Pharmacother, 2023, 169: 115853. DOI: 10.1016/j.biopha.2023.115853.
[6]	Tian Y, Cheng C, Wei Y, et al. The role of exosomes in inflammatory diseases and tumor-related inflammation[J]. Cells, 2022, 11(6): 1005. DOI: 10.3390/cells11061005.
[7]	Hoshino A, Costa-Silva B, Shen TL, et al. Tumour exosome integrins determine organotropic metastasis[J]. Nature, 2015, 527(7578): 329-335. DOI: 10.1038/nature15756.
[8]	Li S, Qu Y, Liu L, et al. Tumour-derived exosomes in liver metastasis: a pandora's box[J]. Cell Prolif, 2023, 56(10): e13452. DOI: 10.1111/cpr.13452.
[9]	Ji Q, Zhou L, Sui H, et al. Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation[J]. Nat Commun, 2020, 11(1): 1211. DOI: 10.1038/s41467-020-14869-x. pmid: 32139701
[10]	Wang C, Tsai S. Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis[J]. Exp Biol Med (Maywood), 2021, 246(19): 2048-2056. DOI: 10.1177/15353702211021022.
[11]	Sun B, Zhou Y, Fang Y, et al. Colorectal cancer exosomes induce lymphatic network remodeling in lymph nodes[J]. Int J Cancer, 2019, 145(6): 1648-1659. DOI: 10.1002/ijc.32196. pmid: 30734278
[12]	Hu H, Yu C, Zhang H, et al. Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2[J]. Int J Biol Macromol, 2019, 132: 470-477. DOI: 10.1016/j.ijbiomac.2019.03.221.
[13]	He Q, Ye A, Ye W, et al. Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1[J]. Cell Death Dis, 2021, 12(6): 576. DOI: 10.1038/s41419-021-03803-8. pmid: 34088891
[14]	Dokhanchi M, Pakravan K, Zareian S, et al. Colorectal cancer cell-derived extracellular vesicles transfer miR-221-3p to promote endothelial cell angiogenesis via targeting suppressor of cytokine signaling 3[J]. Life Sci, 2021, 285: 119937. DOI: 10.1016/j.lfs.2021.119937.
[15]	Shang A, Wang X, Gu C, et al. Exosomal miR-183-5p promotes angiogenesis in colorectal cancer by regulation of FOXO1[J]. Aging (Albany NY), 2020, 12(9): 8352-8371. DOI: 10.18632/aging.103145.
[16]	Chen C, Liu Y, Liu L, et al. Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway[J]. J Exp Clin Cancer Res, 2023, 42(1): 46. DOI: 10.1186/s13046-023-02619-y. pmid: 36793126
[17]	Hu G, Lin C, Gao K, et al. Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer[J]. Mol Med, 2023, 29(1): 155. DOI: 10.1186/s10020-023-00747-x. pmid: 37940881
[18]	Li Y, Jiang D, Zhang Z, et al. Colorectal cancer cell-secreted exosomal miRNA N-72 promotes tumor angiogenesis by targeting CLDN18[J]. Am J Cancer Res, 2023, 13(8): 3482-3499. pmid: 37693144
[19]	Dou R, Liu K, Yang C, et al. EMT-cancer cells-derived exosomal miR-27b-3p promotes circulating tumour cells-mediated metastasis by modulating vascular permeability in colorectal cancer[J]. Clin Transl Med, 2021, 11(12): e595. DOI: 10.1002/ctm2.595. pmid: 34936736
[20]	Jiang K, Chen H, Fang Y, et al. Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness[J]. J Exp Clin Cancer Res, 2021, 40(1): 21. DOI: 10.1186/s13046-020-01816-3. pmid: 33413536
[21]	Zhao S, Mi Y, Guan B, et al. Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer[J]. J Hematol Oncol, 2020, 13(1): 156. DOI: 10.1186/s13045-020-00991-2.
[22]	Chen C, Yao X, Xu Y, et al. Dahuang zhechong pill suppresses colorectal cancer liver metastasis via ameliorating exosomal CCL2 primed pre-metastatic niche[J]. J Ethnopharmacol, 2019, 238: 111878. DOI: 10.1016/j.jep.2019.111878.
[23]	Liang Z, Liu H, Wang F, et al. LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization[J]. Cell Death Dis, 2019, 10(11): 829. DOI: 10.1038/s41419-019-2077-0.
[24]	Wang D, Wang X, Si M, et al. Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages[J]. Cancer Lett, 2020, 474: 36-52. DOI: 10.1016/j.canlet.2020.01.005. pmid: 31931030
[25]	Pei W, Wei K, Wu Y, et al. Colorectal cancer tumor cell-derived exosomal miR-203a-3p promotes CRC metastasis by targeting PTEN-induced macrophage polarization[J]. Gene, 2023, 885: 147692. DOI: 10.1016/j.gene.2023.147692.
[26]	Furumaya C, Martinez-Sanz P, Bouti P, et al. Plasticity in pro- and anti-tumor activity of neutrophils: shifting the balance[J]. Front Immunol, 2020, 11: 2100. DOI: 10.3389/fimmu.2020.02100. pmid: 32983165
[27]	Shang A, Gu C, Wang W, et al. Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p-TGF-β1 axis[J]. Mol Cancer, 2020, 19(1): 117. DOI: 10.1186/s12943-020-01235-0.
[28]	Sun H, Meng Q, Shi C, et al. Hypoxia-inducible exosomes facilitate liver-tropic premetastatic niche in colorectal cancer[J]. Hepatology, 2021, 74(5): 2633-2651. DOI: 10.1002/hep.32009.
[29]	Huang Y, Luo Y, Ou W, et al. Exosomal lncRNA SNHG10 derived from colorectal cancer cells suppresses natural killer cell cytotoxicity by upregulating INHBC[J]. Cancer Cell Int, 2021, 21(1): 528. DOI: 10.1186/s12935-021-02221-2. pmid: 34641864
[30]	Hu X, Lin Z, Wang Z, et al. Emerging role of PD-L1 modification in cancer immunotherapy[J]. Am J Cancer Res, 2021, 11(8): 3832-3840. pmid: 34522452
[31]	Xian D, Niu L, Zeng J, et al. LncRNA KCNQ1OT1 secreted by tumor cell-derived exosomes mediates immune escape in colorectal cancer by regulating PD-L1 ubiquitination via miR-30a-5p/USP22[J]. Front Cell Dev Biol, 2021, 9: 653808. DOI: 10.3389/fcell.2021.653808.
[32]	Sun W, Cui J, Ge Y, et al. Tumor stem cell-derived exosomal microRNA-17-5p inhibits anti-tumor immunity in colorectal cancer via targeting SPOP and overexpressing PD-L1[J]. Cell Death Discov, 2022, 8(1): 223. DOI: 10.1038/s41420-022-00919-4. pmid: 35461336
[33]	Poggio M, Hu TY, Pai CC, et al. Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory[J]. Cell, 2019, 177(2): 414-427.e13. DOI: 10.1016/j.cell.2019.02.016. pmid: 30951669
[34]	Yuan Z, Li Y, Zhang S, et al. Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments[J]. Mol Cancer, 2023, 22(1): 48. DOI: 10.1186/s12943-023-01744-8. pmid: 36906534
[35]	Tian F, Wang P, Lin D, et al. Exosome-delivered miR-221/222 exacerbates tumor liver metastasis by targeting SPINT1 in colorectal cancer[J]. Cancer Sci, 2021, 112(9): 3744-3755. DOI: 10.1111/cas.15028.
[36]	Kamerkar S, Leng C, Burenkova O, et al. Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity[J]. Sci Adv, 2022, 8(7): eabj7002. DOI: 10.1126/sciadv.abj7002.