Relationship between Vav3 and malignant tumors

doi:10.3760/cma.j.cn371439-20240215-00097

Abstract

Abstract:

Vav guanine nucleotide exchange factor 3 （Vav3） protein is one of the guanine nucleotide exchange factors of the Rho family GTPases. It is encoded by the proto-oncogene Vav3 and is involved in the regulation of cell proliferation and apoptosis， differentiation， migration， etc. In recent years， Vav3 has been closely related to the development of a variety of malignant tumors. In glioma， breast cancer， non-small cell lung cancer， gastric cancer， pancreatic cancer， colorectal cancer， prostate cancer， ovarian cancer， osteosarcoma and acute leukemia， the expression of Vav3 is elevated to varying degrees， and it participates in regulating multiple signaling pathways， which promotes the progression of tumors and affects the prognosis of patients. Therefore， Vav3 is expected to be a potential therapeutic target for these malignant tumors.

Key words: Neoplasms, Vav guanine nucleotide exchange factor 3

Shi Xuebing, Wu Jing, Deng Wenxia. Relationship between Vav3 and malignant tumors[J]. Journal of International Oncology, 2024, 51(9): 585-589.

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