Correlation between PD-L1 and Tregs in tumor immunity and immunotherapy

doi:10.3760/cma.j.cn371439-20200907-00066

Abstract

Abstract:

Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) are important co-inhibitory molecules, while regulatory T cells (Tregs) are important suppressor cells. The increase of them in tumor microenvironment is closely related to tumor immune escape and tumor development. PD-L1 plays an important role in the development and function of Tregs. The application of PD-1/PD-L1 blockade also affects the proliferation and function of Tregs, which further participates in the occurrence of drug resistance and hyperprogressive disease. Further understanding of the role and correlation of PD-L1 and Tregs in tumor immunity and immunotherapy can provide new ideas for improving the efficacy of PD-1/PD-L1 blockade.

Key words: Tumor escape, T-lymphocytes,regulatory, PD-1/PD-L1, Immunotherapy

Ou Huiyi, Wang Yue, Peng Chenghong. Correlation between PD-L1 and Tregs in tumor immunity and immunotherapy[J]. Journal of International Oncology, 2021, 48(6): 350-353.

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