Journal of International Oncology ›› 2021, Vol. 48 ›› Issue (2): 109-112.doi: 10.3760/cma.j.cn371439-20200629-00021

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Blood biomarkers for breast cancer screening and early diagnosis

Li Lixi, Ma Fei()   

  1. Department of Medical Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  • Received:2020-06-29 Revised:2020-07-11 Online:2021-02-08 Published:2021-03-11
  • Contact: Ma Fei E-mail:drmafei@126.com
  • Supported by:
    National Natural Science Foundation of China(81874122)

Abstract:

Breast cancer screening is an economical, effective, and simple screening measure for asymptomatic people to achieve the goals of early detection, early diagnosis and early treatment. Existing screening methods are mainly based on breast cancer X-rays and ultrasound, which are less sensitive to early lesions and cannot assess the risk of breast cancer in asymptomatic people. Breast cancer susceptibility genes, DNA methylation, microRNAs and circulating tumor cells, as blood biomarkers for breast cancer screening and early diagnosis, can identify high-risk breast cancer populations and improve the early diagnosis rate of breast cancer.

Key words: Breast neoplasms, Genetic testing, Early diagnosis, Biomarker